553677-86-4Relevant articles and documents
Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: Synthesis and initial structure-activity relationships
Buckley, George M.,Davies, Natasha,Dyke, Hazel J.,Gilbert, Philip J.,Hannah, Duncan R.,Haughan, Alan F.,Hunt, Caroline A.,Pitt, William R.,Profit, Rachael H.,Ray, Nicholas C.,Richard, Marianna D.,Sharpe, Andrew,Taylor, Alicia J.,Whitworth, Justine M.,Williams, Sophie C.
, p. 751 - 754 (2005)
The development of a series of novel quinazolinethiones and quinazolinediones as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis, in vitro inhibitory values for IMPDH II and in vitro inhibitory value for PBMC proliferation are discussed.
