55368-38-2Relevant articles and documents
Metal-Free Photocatalytic Hydrogenation Using Covalent Triazine Polymers
He, Qing,Hu, Yongpan,Huang, Wei,Li, Yanguang,Li, Youyong,Wang, Hongshuai,Yang, Ping,Zhou, Yuan
supporting information, p. 14378 - 14382 (2020/07/04)
Photocatalytic hydrogenation of biomass-derived organic molecules transforms solar energy into high-energy-density chemical bonds. Reported herein is the preparation of a thiophene-containing covalent triazine polymer as a photocatalyst, with unique donor-acceptor units, for the metal-free photocatalytic hydrogenation of unsaturated organic molecules. Under visible-light illumination, the polymeric photocatalyst enables the transformation of maleic acid into succinic acid with a production rate of about 2 mmol g?1 h?1, and furfural into furfuryl alcohol with a production rate of about 0.5 mmol g?1 h?1. Great catalyst stability and recyclability are also measured. Given the structural diversity of polymeric photocatalysts and their readily tunable optical and electronic properties, metal-free photocatalytic hydrogenation represents a highly promising approach for solar energy conversion.
Asymmetric Covalent Triazine Framework for Enhanced Visible-Light Photoredox Catalysis via Energy Transfer Cascade
Huang, Wei,Byun, Jeehye,R?rich, Irina,Ramanan, Charusheela,Blom, Paul W. M.,Lu, Hao,Wang, Di,Caire da Silva, Lucas,Li, Run,Wang, Lei,Landfester, Katharina,Zhang, Kai A. I.
supporting information, p. 8316 - 8320 (2018/06/29)
Complex multiple-component semiconductor photocatalysts can be constructed that display enhanced catalytic efficiency via multiple charge and energy transfer, mimicking photosystems in nature. In contrast, the efficiency of single-component semiconductor photocatalysts is usually limited due to the fast recombination of the photogenerated excitons. Here, we report the design of an asymmetric covalent triazine framework as an efficient organic single-component semiconductor photocatalyst. Four different molecular donor–acceptor domains are obtained within the network, leading to enhanced photogenerated charge separation via an intramolecular energy transfer cascade. The photocatalytic efficiency of the asymmetric covalent triazine framework is superior to that of its symmetric counterparts; this was demonstrated by the visible-light-driven formation of benzophosphole oxides from diphenylphosphine oxide and diphenylacetylene.
Synthesis and evaluation of thiophene-based guanylhydrazones (iminoguanidines) efficient against panel of voriconazole-resistant fungal isolates
Ajda?i?, Vladimir,Senerovic, Lidija,Vrani?, Marija,Pekmezovic, Marina,Arsic-Arsnijevic, Valentina,Veselinovic, Aleksandar,Veselinovic, Jovana,?olaja, Bogdan A.,Nikodinovic-Runic, Jasmina,Opsenica, Igor M.
, p. 1277 - 1291 (2016/03/01)
A series of new thiophene-based guanylhydrazones (iminoguanidines) were synthesized in high yields using a straightforward two-step procedure. The antifungal activity of compounds was evaluated against a wide range of medicaly important fungal strains inc
The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease
Opsenica, Igor,Filipovic, Vuk,Nuss, Jon E.,Gomba, Laura M.,Opsenica, Dejan,Burnett, James C.,Gussio, Rick,Solaja, Bogdan A.,Bavari, Sina
experimental part, p. 374 - 379 (2012/08/08)
Botulinum neurotoxins (BoNTs), composed of a family of seven serotypes (categorized A-G), are the deadliest of known biological toxins. The activity of the metalloprotease, light chain (LC) component of the toxins is responsible for causing the life-threatening paralysis associated with the disease botulism. Herein we report significantly more potent analogs of novel, lead BoNT serotype A LC inhibitor 2,5-bis(4-amidinophenyl)thiophene (Ki = 10.88 μM ± 0.90 μM). Specifically, synthetic modifications involved simultaneously replacing the lead inhibitor's terminal bis-amidines with secondary amines and the systematic tethering of 4-amino-7-chloroquinoline substituents to provide derivatives with Ki values ranging from 0.302 μM (±0.03 μM) to 0.889 μM (±0.11 μM).
Palladium-catalysed direct arylation of thiophenes tolerant to silyl groups
Chen, Lu,Roger, Julien,Bruneau, Christian,Dixneuf, Pierre H.,Doucet, Henri
supporting information; experimental part, p. 1872 - 1874 (2011/04/15)
The palladium catalysed 5-arylation of 2-(trimethylsilyl)thiophene with aryl bromides via C-H bond functionalisation allows the synthesis of arylated silylthiophenes in only one step.
Direct 2-arylation of thiophene using low loading of a phosphine-free palladium catalyst
Bensaid, Souhila,Roger, Julien,Beydoun, Kassem,Roy, David,Doucet, Henri
experimental part, p. 3524 - 3531 (2011/09/16)
The direct coupling of aryl halides with thiophene would be a considerable advantage for sustainable development because of only HBr associated with a base as by-product is formed and the number of steps to prepare these compounds is less than in more cla
Antileishmanial activities of several classes of aromatic dications
Brendle, James J.,Outlaw, Abram,Kumar, Arvind,Boykin, David W.,Patrick, Donald A.,Tidwell, Richard R.,Werbovetz, Karl A.
, p. 797 - 807 (2007/10/03)
Aromatic dicationic molecules possess impressive activity against a broad spectrum of microbial pathogens, including Pneumocystis carinii, Cryptosporidium parvum, and Candida albicans. In this work, 58 aromatic cations were examined for inhibitory activity against axenic amastigote-like Leishmania donovani parasites. In general, the most potent of the compounds were substituted diphenyl furan and thiophene dications. 2,5-Bis-(4-amidinophenyl)thiophene was the most active compound. This agent displayed a 50% inhibitory concentration (IC50) of 0.42 ± 0.08 μM against L. donovani and an in vitro antileishmanial potency 6.2-fold greater than that of the clinical antileishmanial dication pentamidine and was 155-fold more toxic to the parasites than to a mouse macrophage cell line. 2,4-Bis-(4-amidinopheny)furan was twice as active as pentamidine (IC50, 1.30 ± 0.21 μM), while 2,5-bis-(4-amidinopheny)furan and pentamidine were essentially equipotent in our in vitro antileishmanial assay. Carbazoles, dibenzofurans, dibenzothiophenes, and benzimidazoles containing amidine or substituted amidine groups were generally less active than the diphenyl furans and thiophenes. In all cases, aromatic dications possessing strong antileishmanial activity were severalfold more toxic to the parasites than to a cultured mouse macrophage cell line. These structure-activity relationships demonstrate the potent antileishmanial activity of several aromatic dications and provide valuable information for the future design and synthesis of more potent antiparasitic agents.
