55394-80-4Relevant academic research and scientific papers
C-Alkylation of N-alkylamides with styrenes in air and scale-up using a microwave flow reactor
Barham, Joshua P.,Tamaoki, Souma,Egami, Hiromichi,Ohneda, Noriyuki,Okamoto, Tadashi,Odajima, Hiromichi,Hamashima, Yoshitaka
, p. 7568 - 7573 (2018)
C-Alkylation of N-alkylamides with styrenes is reported, proceeding in ambient air/moisture to give arylbutanamides and pharmaceutically-relevant scaffolds in excellent mass balance. Various amide and styrene derivatives were tolerated, rapidly affording molecular complexity in a single step; thus highlighting the future utility of this transformation in the synthetic chemistry toolbox. Reaction scalability (up to 65 g h-1 product) was demonstrated using a Microwave Flow reactor, as the first example of a C-alkylation reaction using styrenes in continuous flow.
