55395-30-7Relevant academic research and scientific papers
The use of 2-chloro-4H-4-oxo-pyrido[1,2-a]pyrimidine as a building block in the synthesis of some new heterocyclic compounds
Badawy, Doria S.,Awad, Noha M.,Abdel-Galil, Ebrahim
, p. 1351 - 1356 (2013)
New approaches for the synthesis of some heterocyclic compounds, such as the pyridopyrimidodiazepine derivative 3, pyrazolopyrido[1,2-a]pyrimidine derivative 4, tetrazolo[1.5-a][1,8]naphthyridine derivative 9, pyrazolylpyrido[1,2-a]pyrimidine derivatives 10a,10b,12, pyrrolopyrido[1,2-a] pyrimidine derivatives 14a, 14b, 14c, 14d, and 16a,16b, starting from 2-chloro-4H-4-oxo-pyrido[1,2-a]pyrimidine (1), are described.
Substituted pyridopyrimidinones. Part IV. 2-Chloro-4H-pyrido[1,2-a]pyrimidin-4-one as a synthone of some new heterotricycles
Abass, Mohamed,Ismail, Mostafa M.,Abdel-Monem, Wafaa R.,Mayas, Aisha S.
experimental part, p. 11 - 17 (2010/11/05)
2-Chloro-4H-pyrido[1,2-a]pyrimidin-4-one (1) was utilized as a synthone precursor to prepare novel heterotricyclic systems. 2-Azido and 2-hydrazino derivatives (2 and 3) were obtained by nucleophilic replacement evolving compound 1. The hydrazine derivative 3 was transformed into the azido derivative 2 by nitrosation. Treatment of compound 3 with [bis(methylthio)methylene] malononitrile afforded 2-pyrazolylpyridopyrimidine 4. When compound 1 was reacted with 5-amino-3-(methylthio)-1H-pyrazole-4-carbonitrile, the same compound 4 was obtained with no evidence for the production of (pyrazolylamino) pyridopyrimidine 5 or pyrazolodipyridopyrimidine 6. Poly-functionalized dipyridopyrimidine 8 was obtained by reaction of compound 1 with 2-[(methylthio)-(phenylamino)methylene]propanedinitrile. Cyanoguanidine was reacted with compound 1 to afford N-pyridopyrimidinylguanidine 9, which was subjected to cyclization reaction, in presence of piperidinium acetate, to give pyridopyrimidopyrimidine 10. 2009 Copyright (CC) SCS.
