55404-29-0

Basic information

• Product Name: 4-NITRO-ISOQUINOLIN-1-OL
• Synonyms: 4-NITRO-ISOQUINOLIN-1-OL;1-Hydroxy-4-nitroisoquinoline;4-Nitro-1(2H)-isoquinolinone;4-Nitro-1-hydroxyisoquinoline;4-Nitro-1-isoquinolinol;4-NITROISOQUINOLIN-1(2H)-ONE;4-nitroisoquinolin-1-ol/4-nitroisoquinolin-1(2H)-one;(25R)-SPIROST-5-ENE-2WEI ,3WEI -DIOL
• CAS NO: 55404-29-0
• Molecular Formula: C₉H₆N₂O₃
• Molecular Weight: 190.16
• Mol File: 55404-29-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 436℃
• Flash Point: 217℃
• Appearance: /
• Density: 1.45
• Vapor Pressure: 8.69E-08mmHg at 25°C
• Refractive Index: 1.657
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.45±0.20(Predicted)
• CAS DataBase Reference: 4-NITRO-ISOQUINOLIN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITRO-ISOQUINOLIN-1-OL(55404-29-0)
• EPA Substance Registry System: 4-NITRO-ISOQUINOLIN-1-OL(55404-29-0)

Safety Data

• Hazardous Substances Data: 55404-29-0(Hazardous Substances Data)

Usage

General Description

4-NITRO-ISOQUINOLIN-1-OL is a chemical compound with the molecular formula C9H6N2O3. It is a nitro-substituted isoquinolin-1-ol derivative, which has a nitro group (-NO2) attached to the 4-position of the isoquinolin-1-ol ring. 4-NITRO-ISOQUINOLIN-1-OL is primarily used as a building block and intermediate in the synthesis of various pharmaceuticals and organic compounds. It has potential applications in the development of drugs with anti-inflammatory, antiviral, and antitumor properties. Additionally, 4-NITRO-ISOQUINOLIN-1-OL can be utilized in the production of dyes, pigments, and other specialty chemicals due to its unique chemical structure and reactivity.

InChI:InChI=1/C9H6N2O3/c12-9-7-4-2-1-3-6(7)8(5-10-9)11(13)14/h1-5H,(H,10,12)

Upstream product

• 491-30-5 1-hydroxyisoquinoline 
• 491-30-5 1-isoquinolone 
• 936240-67-4 1-amino-4-nitroisoquinoline sulfate 

Downstream Products

• 1015-89-0 6(5H)-phenanthridinone 
• 1610343-51-5 1-(1',4-dimethyl-1-phenyl-1H,1'H-[3,4'-bipyrazol]-5-yl)-3-(1-oxo-2-(2,2,2-trifluoroethyl)-1,2-dihydroisoquinolin-4-yl)urea 
• 78886-53-0 4-aminoisoquinolin-1-ol 
• 65092-53-7 1-chloro-4-nitroisoquinoline 
• 64352-53-0 3-hydroxyphenanthridin-6(5H)-one 

Relevant articles and documents

IN-FLOW PHOTOOXYGENATION OF AMINOTHIENOPYRIDINONES GENERATES NOVEL PTP4A3 PHOSPHATASE INHIBITORS

The disclosure provides compounds that inhibit protein tyrosine phosphatase, such as protein tyrosine phosphatase 4A3 (PTP4A3). The disclosure also provides pharmaceutical compositions, uses, and methods of using the compounds, such as in the treatment of cancers. (I), wherein X is O or NH.

1,4-SUBSTITUTED ISOQUINOLINE INHIBITORS OF KEAP1/NRF2 PROTEIN-PROTEIN INTERACTION

Disclosed herein are compounds that can act as inhibitors of the Kelch-like ECH- associated protein 1/nuclear factor (erythroid-derived 2)-like 2 ("KEAP1/NRF2") protein- protein interaction, and methods of using the compounds to treat and prevent diseases and disorders, such as COPD, multiple sclerosis, and diabetes, and in the promotion of wound healing. The compounds described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: formula (I), wherein the substituents are as described.

PYRAZOLE-ISOQUINOLINE UREA DERIVATIVES AS P38 KINASE INHIBITORS

The present invention provides kinase inhibitors of Formula (I) wherein R1, R2, and X are as described herein, or a pharmaceutically acceptable salt thereof.