55405-89-5Relevant academic research and scientific papers
Chemoselective Reduction of Azlactones Using Schwartz's Reagent
Pinheiro, Danielle L. J.,ávila, Eloah P.,Batista, Gabriel M. F.,Amarante, Giovanni W.
, p. 5981 - 5985 (2017/06/07)
Highly chemoselective addition of Schwartz's reagent to widely available azlactones is described. This method allows the preparation of challenged functionalized α-amino aldehydes, in good to high isolated yields at room temperature, after only 2 min reaction. The presence of sensitive functionalities or electronic factors does not compromise the potential of the method. The use of an excess of the reducing reagent gave a very functionalized allylic alcohol derivative in 86% yield.
β-Amidoaldehydes via oxazoline hydroformylation
Laitar, David S.,Kramer, John W.,Whiting, Bryan T.,Lobkovsky, Emil B.,Coates, Geoffrey W.
supporting information; experimental part, p. 5704 - 5706 (2010/01/31)
4-Substituted oxazolines, which are readily synthesized from naturally occurring α-amino acids, are converted efficiently and stereospecifically to β-amidoaldehydes in the presence of synthesis gas and catalytic dicobalt octacarbonyl.
Asymmetric electrochemical oxidation of 1,2-diols, aminoalcohols, and?aminoaldehydes in the presence of chiral copper catalyst
Minato, Daishirou,Arimoto, Hitomi,Nagasue, Yoko,Demizu, Yosuke,Onomura, Osamu
, p. 6675 - 6683 (2008/12/20)
Asymmetric oxidation of 1,2-diols, aminoalcohols, and aminoaldehydes in the presence of copper(II) triflate and (R,R)-Ph-BOX was accomplished by electrochemical method using Br- as a mediator. This oxidation was applicable to kinetic resolution of racemic cis-cycloalkane-1,2-diols, aminoalcohols, and aminoaldehydes to afford optically active compounds with good to high enantioselectivity.
Effecient kinetic resolution of racemic amino aldehydes by oxidation with N-iodosuccinimide
Minato, Daishirou,Nagasue, Yoko,Demizu, Yosuke,Onomura, Osamu
supporting information; experimental part, p. 9458 - 9461 (2009/05/06)
(Chemical Equation Presented) Selective recognition: The first efficient method for the kinetic resolution of racemic amino aldehydes (see scheme, PG=protecting group) is based on a copper(II)/(R,R)-Ph-BOX complex. The coordinated amino aldehydes were tra
A versatile approach to 3-alkyl and 2,3-dialkylpyrroles
Burley,Bilic,Hewson,Newton
, p. 8969 - 8972 (2007/10/03)
A route is described towards N-Benzoyl-3-Alkyl and N-Benzoyl-2,3-Dialkyl pyrroles from α-Amidoketones via an intramolecular Wittig reaction to afford 4-Phenylthio-3-Pyrrolines which are then oxidised to the corresponding sulphones and aromatised by treatm
