7260-27-7

Basic information

• Product Name: methyl 2-benzamidopropanoate
• CAS NO: 7260-27-7
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.229
• Mol File: 7260-27-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 383.3°Cat760mmHg
• Flash Point: 185.6°C
• Density: 1.131g/cm³
• CAS DataBase Reference: methyl 2-benzamidopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-benzamidopropanoate(7260-27-7)
• EPA Substance Registry System: methyl 2-benzamidopropanoate(7260-27-7)

Safety Data

• Hazardous Substances Data: 7260-27-7(Hazardous Substances Data)

Upstream product

• 7244-67-9 methyl N-benzoylalaninate 
• 186581-53-3 diazomethane 
• 17966-60-8 D-N-benzoylalanine 
• 67-56-1 methanol 
• 51127-13-0 2-phenyl-4-methyl-4H-oxazolin-5-one 
• 55405-89-5 N-(1-formylethyl)benzamide 
• 149032-75-7 (3R,6R)-N-Benzoyl-3,6-dihydro-3-methyl-2H-1,2-oxazin-6-carbonsaeure-ethylester 
• 180311-17-5 Benzoic acid 2'-(2-benzoylamino-propionyloxy)-[1,1']binaphthalenyl-2-yl ester 
• 98-88-4 benzoyl chloride 
• 149032-76-8 (Z)-(2R,5R)-5-Benzamido-2-hydroxy-3-hexensaeure-ethylester 

Downstream Products

• 65563-98-6 2-benzoylamino-2-methyl-propionic acid methyl ester 
• 117918-29-3 dimethyl 2,3-dibenzamido-2,3-dimethylbutanedioate 

Relevant articles and documents

Benzotetramisole-catalyzed dynamic kinetic resolution of azlactones

(Figure Presented) Enantioselective acyl transfer catalyst benzotetramisole (BTM) has been found to promote dynamic kinetic resolution of azlactones providing di(1-naphthyl)methyl esters of α-amino acids with up to 96% ee.

Asymmetric electrochemical oxidation of 1,2-diols, aminoalcohols, and?aminoaldehydes in the presence of chiral copper catalyst

Asymmetric oxidation of 1,2-diols, aminoalcohols, and aminoaldehydes in the presence of copper(II) triflate and (R,R)-Ph-BOX was accomplished by electrochemical method using Br- as a mediator. This oxidation was applicable to kinetic resolution of racemic cis-cycloalkane-1,2-diols, aminoalcohols, and aminoaldehydes to afford optically active compounds with good to high enantioselectivity.

Enantioselective enolate protonation: Matching chiral aniline and substrate acidity

A comparison of chiral anilines 1a-f in the asymmetric protonation of enolate 15 shows that the optimum ΔpK(a) value (chiral acid vs protonated enolate) for the highest enantioselectivity is ca. 3 (Table 2). An extension of this concept to amino acid enolates was possible, and 1e was found to give the best enantioselectivity (85% ee) with the alanine-derived N-lithioenolate 5a (Table 3). Changes in aniline pK(a) due to variation of substituents at the aniline nitrogen were evaluated briefly, but these changes did not show consistent trends in the enantioselectivity vs pK(a).