55413-89-3Relevant articles and documents
Synthesis of further amino-halogen-substituted phenyl-aminoethanols
Kruger,Keck,Noll,Pieper
, p. 1612 - 1624 (2007/10/02)
Starting from clenbuterol as a lead structure, new 4-amino-phenyl-aminoethanol analogues have been synthesized by different approaches. In these compounds one or both of the chlorine atoms of clenbuterol are replaced by other residues. This has led to compounds with high intrinsic β2-mimetic and/or β1-blocking activities. 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol hydrochloride (mabuterol) has been selected for clinical development. A detailed description is also given of the syntheses of new intermediate acetophenone derivatives as well as of the resolution of mabuterol into its enantiomers.
Aminobenzyl-amides and salts thereof
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, (2008/06/13)
Compounds of the formula SPC1 Wherein R1 is hydrogen or aliphatic or aromatic carboxylic acyl, R2 is hydrogen, chlorine or bromine, R3 is fluorine, alkyl of 1 to 4 carbon atoms, trifluoromethyl, cyano, carbamoyl, carboxyl,