55418-16-1

Upstream product

• 72-40-2 5-aminoimidazole-4-carboxamide hydrochloride 
• 123-54-6 acetylacetone 
• 360-97-4 4-amino-5-imidazolecarboxamide 

Relevant academic research and scientific papers

SUBSTITUTED IMIDAZO[1,5-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted imidazo[1,5-a]pyrimidines and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted imidazo[1,5-a]pyrimidine compounds described herein include substituted 2,4-dimethyl-N-phenylimidazo[1,5-a]pyrimidine-8-carboxamide compounds and variants thereof.

Concerning the identity test for caffeine in the pharmacopoeia. Part 1: Imidazo[1,5-a]pyrimidinium salts

Since the edition of the DAB 9 a specific reaction is proposed as identity test for caffeine. According to the literature, at first a hydrolysis to caffeidine occurs with following reaction to the enaminone of acetylacetone. Model experiments however show

HETEROCYCLIC COMPOUNDS. I. REACTIONS OF o-AMINO-CARBOXAMIDE WITH β-DIKETONES: SYNTHESIS OF IMIDAZOPYRIMIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES

Treatment of 5-aminoimidazole-4-carboxamide hydrochloride (1) and 5-aminopyrazole-4-carboxamide hemisulfate (2) with β-diketones furnished 2,4-disubstituted imidazopyrimidine-8-carboxamide (7) and 5,7-disubstituted pyrazolopyrimidine-3-carbo