360-97-4Relevant articles and documents
Studies on the biosynthesis of nucleic acids. IV. Synthesis of labeled 4-aminoimidazole-5-carboxamide from barium carbonate-14C.
NOGUCHI
, p. 130 - 132 (1956)
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Screening of microorganisms producing 5 amino 4 imidazole carboxamide and D ribose from 5 amino 4 imidazole carboxamide riboside
Sano,Yokozeki,Mitsugi
, p. 2463 - 2464 (1977)
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Lam et al.
, p. 1391 (1974)
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Development of a One-Step Synthesis of 5-Amino-1 H-imidazole-4-carboxamide
Qi, Ji,Yin, Jingjun,Li, Donghong,Chen, Song,Liu, Zhenguo
, p. 591 - 596 (2021/04/05)
An innovative and efficient synthesis of 5-amino-1H-imidazole-4-carboxamide (AIC) from commercially available hypoxanthine (~$30/kg) is described. The development of the key hydrolysis step and a practical isolation enables a highly efficient one-step manufacturing process for AIC with minimal environmental impact and significant reduction of production cost.
Optimized synthesis process of anticancer drug dacarbazine
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Paragraph 0032; 0033, (2019/10/17)
The invention provides an optimized synthesis process of an anticancer drug dacarbazine. The optimized synthesis process of the anticancer drug dacarbazine comprises the following steps: synthesis ofglycine methyl ester, synthesis of N-formylglycine methyl ester, synthesis of alpha-methyl isocyanoacetate, synthesis of alpha-isocyanoacetamide, synthesis of 5-amino-4-imidazolecarboxamide and synthesis of dacarbazine. Synthesis of the glycine methyl ester comprises the following steps: weighing 7.5 g of glycine and adding the glycine into a 500 mL round-bottom flask, taking 200 mL of redistilledmethanol as a solvent and cooling with stirring in an ice bath for 15 min; weighing 22 mL of thionyl chloride by a syringe and slowly dropwise adding the thionyl chloride into the reaction flask to react overnight at room temperature; and removing excess thionyl chloride and methanol by rotary evaporation at the room temperature, dissolving the residues by using as little hot methanol as possible, quickly adding a large amount of cold diethyl ether, and cooling in the reaction bottle in an ice bath. By improving the synthesis process of the anticancer drug dacarbazine, the optimized synthesisprocess of the anticancer drug dacarbazine has the advantages of reasonable synthesis circuit, cheap raw materials, mild reaction conditions and high total yield, thereby effectively solving the problems and defects in the prior art.