55422-79-2

Basic information

• Product Name: 2,6-bis(chloromethyl)pyridine
• Synonyms: 2,6-BIS(CHLOROMETHYL)PYRIDINE;Nsc244971;2,6-Dichloro-3-methylpyridine hydrochloride;2,6-Bis-(Chloromethyl)-pyridine HCL
• CAS NO: 55422-79-2
• Molecular Formula: C₇H₇Cl₂N*ClH
• Molecular Weight: 176.04
• Mol File: 55422-79-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 286.8 °C at 760 mmHg
• Flash Point: 127.2 °C
• Appearance: /
• Density: 1.275 g/cm3
• Vapor Pressure: 0.00197mmHg at 25°C
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2,6-bis(chloromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-bis(chloromethyl)pyridine(55422-79-2)
• EPA Substance Registry System: 2,6-bis(chloromethyl)pyridine(55422-79-2)

Safety Data

• Hazardous Substances Data: 55422-79-2(Hazardous Substances Data)

Usage

General Description

2,6-bis(chloromethyl)pyridine is a chemical compound with the molecular formula C7H7Cl2N. It is a derivative of pyridine, a six-membered ring with five carbon atoms and one nitrogen atom. The compound contains two chloromethyl groups attached to the 2 and 6 positions of the pyridine ring. It is a colorless to light yellow liquid with a strong, pungent odor. 2,6-bis(chloromethyl)pyridine is commonly used in organic synthesis as a reagent for the preparation of various chemical compounds. It is also a precursor to the synthesis of pharmaceuticals, pesticides, and other industrial chemicals. However, it is important to handle this compound with caution as it is toxic and can cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C7H7Cl2N.ClH/c8-4-6-2-1-3-7(5-9)10-6;/h1-3H,4-5H2;1H

Upstream product

• 63071-12-5 (6-methoxy-pyridin-2-yl)-methanol 
• 1195-59-1 2.6-bis(hydroxymethyl)pyridine 
• 108-48-5 2,6-dimethylpyridine 
• 499-83-2 Pyridine-2,6-dicarboxylic acid 

Downstream Products

• 628308-52-1 2-{[6-(chloromethyl)pyridin-2-yl]methyl}isoindoline-1,3-dione 
• 90719-78-1 2,6-bis{[(pyrid-2-ylmethyl)(tosyl)amino]methyl}pyridine 

Relevant articles and documents

Preparation method of 2,6-chloromethylpyridine hydrochloride (by machine translation)

The invention belongs to the field, of organic synthesis, and particularly relates to 2,6 -chloromethylpyridine hydrochloride, preparation method :(1), which comprises the following steps 2,6 - reacting,dimethylaminopyridine as a raw material 2,6 - to prepare ;(2)2,6 -picolinic acid dimethyl 2,6 -picolinic acid dimethyl ;(3)2,6 -pyridine dimethanol and thionyl chloride to obtain a target product 2,6 -dichloromethylpyridine dihydrochloride with methanol in an acidic condition ;(4)2,6 - The method comprises the following steps: reacting 2,6 - with a commonly-used chemical raw material containing a pyridine ring and methanol in an acidic condition. The method disclosed by the invention is suitable for industrial, production : (by machine translation)

Synthesis and characterization of PY2- and TPA-appended diphenylglycoluril receptors and their bis-CuI complexes

A number of metallohosts mimicking dinuclear copper oxygenases have been designed and synthesized. These metallohosts combine a substrate binding site, i.e. the diphenylglycoluril basket receptor, with two types of metal-binding ligands, viz. tri-coordinating bis(2-ethylpyridine)amine (PY2) and tetra-coordinating tris(2-methylpyridine)amine (TPA). The preparation of the bis-CuI complexes of the ligand-appended receptors and their characterization by NMR are reported. NMR spectroscopic data provide evidence for a dynamic inclusion behavior of some of the pyridine moieties in the receptor of both the metal-free ligands and the CuI complexes. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

S,S'-bis(pyridylmethyl)-carbonodithioates

S,S'-bis(pyridylmethyl)-carbonodithioates and derivatives thereof have utility in the treatment of rheumatoid arthritis. The compound useful in the method of treatment is prepared from known pyridine derivatives and, principally, from pyridoxine and related compounds.