55434-36-1Relevant academic research and scientific papers
One pot regiospecific synthesis of polysubstituted pyrroles from benzylamines and ynones under metal free conditions
Shen, Jinhai,Cheng, Guolin,Cui, Xiuling
, p. 10641 - 10643 (2013)
A convenient one-pot weak base-promoted synthesis of polysubstituted pyrroles has been developed from benzylamines and ynones. This transformation involves the Michael addition reaction and intramolecular condensation, which features high regioselectivity, high efficiency, environmental friendliness and metal free. A series of polysubstituted pyrroles were provided in up to 91% yield for 27 examples.
One-Pot Synthesis of N-H-Free Pyrroles from Aldehydes and Alkynes
Chen, Lai,Huo, Jing-Qian,Kou, Song,Mao, Jianyou,Si, He-Long,Xu, Xin-Yu,Zhang, Jin-Lin
supporting information, p. 4348 - 4352 (2021/06/27)
The first base-mediated intermolecular cyclization of arylaldehydes and terminal arylacetylenes for the synthesis of a wide range of pyrroles in a single step has been described. The developed methodology used commercially available starting materials and
Iron-Catalyzed Radical Cycloaddition of 2H-Azirines and Enamides for the Synthesis of Pyrroles
Zhao, Mi-Na,Ren, Zhi-Hui,Yang, De-Suo,Guan, Zheng-Hui
, p. 1287 - 1290 (2018/03/09)
A novel and efficient Fe-catalyzed radical cycloaddition of 2H-azirines and enamides for the synthesis of substituted pyrroles has been developed. The radical cycloaddition reaction proceeded through a conceptually new Fe(II)-catalyzed homolytic cleavage of C-N bond of 2H-azirines sequential radical cyclization with enamides. The reaction used readily available starting materials, tolerated various functional groups, and afforded valuable triaryl-substituted pyrroles in good to high yields under mild reaction conditions.
