554416-29-4

Upstream product

• 554416-28-3 (E)-5-hydroxy-1-(tert-butyldiphenylsilyloxymethyl)-2-(tert-butyldimethylsilyloxy)-3-methylpent-2-ene 
• 554416-24-9 ethyl (E)-5-(p-methoxybenzyloxy)-2-iodo-3-methylpent-2-enoate 
• 554416-46-5 (E)-2-Iodo-5-(4-methoxy-benzyloxy)-3-methyl-pent-2-en-1-ol 
• 554416-23-8 5-(4-methoxy-benzyloxy)-pent-2-ynoic acid ethyl ester 
• 554416-47-6 methanesulfonic acid 4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl ester 
• 554416-42-1 2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(4-methoxy-benzyloxy)-3-methyl-pent-2-en-1-ol 
• 554416-26-1 2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(4-methoxy-benzyloxy)-3-methyl-pent-2-enoic acid methyl ester 
• 554416-25-0 (E)-5-(p-methoxybenzyloxy)-1-(tert-butyldimethylsilyloxy)-2-iodo-3-methylpent-2-ene 

Downstream Products

• 554416-32-9 4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbonitrile 
• 554416-43-2 4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbonitrile 
• 554416-33-0 4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbaldehyde 
• 554416-31-8 4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxan-5-one 
• 554416-35-2 (E)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-[(4R,5R)-5-((E)-2-iodo-vinyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-3-methyl-pent-2-en-1-ol 
• 554416-30-7 [(R)-4-[(E)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxan-(5E)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine 

Relevant academic research and scientific papers

New approach toward the total synthesis of (+)-aphidicolin by tandem transannular Diels-Alder/aldol strategy

The synthesis of a 15-membered macrocyclic triene containing all the required substituents of ring A of (+)-aphidicolin (1) is reported. This compound underwent a thermal transannular cycloaddition followed by an intramolecular aldol reaction to yield tet