554420-01-8

Upstream product

• 68579-60-2 2-(methylamino)-1-phenylethanol 
• 115794-66-6 trans-methyl 3-phenylglycidate 
• 121-39-1 (2S,3R)-ethyl 3-phenyloxirane-2-carboxylate 
• 4192-77-2 ethyl cinnamate 
• 14990-09-1 tert-butyl cinnamate 
• 71403-94-6 2,3-epoxy-3-phenylpropanal 
• 104-55-2 3-phenyl-propenal 
• 121651-02-3 (2S,3R)-2-formyl-3-phenyloxirane 

Downstream Products

• 114376-13-5 (3S,4R,5R)-clausenamidone 

Relevant academic research and scientific papers

Method for Preparing Optically Pure (-)-Clausenamide Compound

Disclosed in the present invention is a method for preparing a (?)-clausenamide compound of formula (I), comprising: firstly, catalyzing the asymmetrical epoxidation of trans-cinnamate using a chiral ketone derived from fructose or a hydrate thereof as a catalyst, and then subjecting the product to transesterification, oxidation, cyclization and reduction successively to finally obtain the optically pure (?)-clausenamide compound of formula (I).

Highly efficient asymmetric synthesis of α,β-epoxy esters via one-pot organocatalytic epoxidation and oxidative esterification

Highly enantioselective synthesis of α,β-epoxy esters was achieved via one-pot organocatalytic epoxidation and consequent oxidative esterification. Excellent enantioselectivities (up to 99% ee) and good yields were obtained for a variety of α,β-epoxy esters. The method was readily scaled. Furthermore the product was applied towards the synthesis of (-)-clausenamide with excellent enantioselectivities (>99% ee).