554430-45-4Relevant academic research and scientific papers
Identification and structure - Activity relationships of chromene-derived selective estrogen receptor modulators for treatment of postmenopausal symptoms
Jain, Nareshkumar,Xu, Jiayi,Kanojia, Ramesh M.,Du, Fuyong,Guo, Jian-Zhong,Pacia, Emmanuel,Lai, Muh-Tsann,Musto, Amy,Allan, George,Reuman, Michael,Li, Xun,Hahn, DoWon,Cousineau, Martin,Peng, Sean,Ritchie, David,Russell, Ronald,Lundeen, Scott,Sui, Zhihua
supporting information; experimental part, p. 7544 - 7569 (2010/06/13)
As part of a program aimed at the development of selective estrogen receptor modulators (SERMs), novel chromene scaffolds, benzopyranobenzoxapanes, were discovered. Many compounds showed binding affinity as low as 1.6-200 nM, displayed antagonist behavior
Synthesis of tetracyclic heterocompounds as selective estrogen receptor modulators. Part 2. Process improvement for scale-up of 2,5,8-substituted 11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta-[1,2-a]naphthalene derivatives
Li, Xun,Reuman, Michael,Russell, Ronald K.,Youells, Scott,Beish, Sandra,Hu, Zhiyong,Branum, Shawn,Jain, Nareshkumar,Sui, Zhihua
, p. 731 - 738 (2012/12/29)
An improved, reproducible nonchromatographic process for scale-up synthesis of 2,5,8-substituted 11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a] naphthalene derivatives as selective estrogen receptor modulators (SERMs) is described. The titled comp
Novel heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
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, (2008/06/13)
The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and/or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
Novel heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
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Page/Page column 61, (2010/01/31)
The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and/or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
