554430-80-7Relevant academic research and scientific papers
Synthesis of novel tetracyclic chromenes through carbanion chemistry of 4-methyl coumarins
Chen, Ningyi,Jain, Nareshkumar,Xu, Jiayi,Reuman, Michael,Li, Xun,Russell, Ronald K.,Sui, Zhihua
, p. 5909 - 5913 (2006)
Various substituents were introduced onto the methyl group in 4-methyl coumarins through lithiation, followed by reactions with a wide range of electrophiles. The presence of an alkoxy group on 6′-phenyl ring was found to be pivotal for the success of thi
Novel heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
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Page/Page column 83, (2010/01/31)
The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and/or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
