55457-59-5

Usage

Uses

Used in Research Applications:
8-Brom-2,7-dimethyl-3H-pyrazolo[1,5-a][1,3,5]triazin-4-one is used as a research tool for studying the physiological and pathological role of P2X7 receptors. It helps researchers understand the receptor's involvement in various biological processes and its potential therapeutic applications.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 8-Brom-2,7-dimethyl-3H-pyrazolo[1,5-a][1,3,5]triazin-4-one is used as a lead compound for developing potential therapeutic interventions for diseases associated with P2X7 receptor dysfunction. Its agonistic activity on P2X7 receptors makes it a promising candidate for the treatment of chronic pain, arthritis, and cancer.
Used in Inflammation and Immunity Research:
8-Brom-2,7-dimethyl-3H-pyrazolo[1,5-a][1,3,5]triazin-4-one is used as an activator of the NLRP3 inflammasome, a multiprotein complex involved in the initiation of inflammation. This application aids researchers in understanding the complex interplay between P2X7 receptors and inflammation, as well as the role of the NLRP3 inflammasome in immune responses.
Overall, 8-Brom-2,7-dimethyl-3H-pyrazolo[1,5-a][1,3,5]triazin-4-one is a versatile compound with significant potential in research and pharmaceutical development, particularly in the areas of inflammation, immunity, and neurodegenerative diseases.

Upstream product

• 13932-53-1 ethyl hydrogen carbonate 
• 1304777-34-1 C₆H₉BrN₄ 
• 55785-87-0 2,7-dimethylpyrazolo[1,5-α][1,3,5]triazin-4(3H)-one 

Relevant academic research and scientific papers

Investigating the effects of the core nitrogen atom configuration on the thermodynamic solubility of 6,5-bicyclic heterocycles

Physicochemical properties, such as solubility, are important when prioritising compounds for progression on a drug discovery project. There is limited literature around the systematic effects of core changes on thermodynamic solubility. This work details

HETEROAROMATIC COMPOUNDS USEFUL IN THERAPY

A compound of formula (I) or a pharmaceutically acceptable salt thereof, useful in therapy, in particular in the treatment of a viral infection or a disease linked to impaired or abnormal autophagy.

CONDENSED PYRIMIDINE OR PYRIDAZINE DERIVATIVES AS ANTIVIRAL AGENTS

A compound of formula (I) or a pharmaceutically acceptable salt thereof. The compound is a prodrug of a PI4KIIIβinhibitor and as such is useful as an antiviral agent. A pharmaceutical composition comprising the compound.

Potential CRF1R PET imaging agents: N-Fluoroalkyl-8-(6-methoxy- 2-methylpyridin-3-yl)-2,7-dimethyl-N-alkylpyrazolo[1,5-a][1,3,5]triazin-4-amines

A series of N-fluoroalkyl-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl- N-alkylpyrazolo[1,5-a][1,3,5]triazin-4-amines were prepared and evaluated as potential CRF1R PET imaging agents. Optimization of their CRF 1R binding potencies and octanol-phosphate buffer phase distribution coefficients resulted in discovery of analog 7e (IC50 = 6.5 nM, log D = 3.5).