5548-30-1

Upstream product

• 5600-82-8 2,5-dimethoxy-3-methylphenylmethanol 
• 886503-93-1 5-methoxy-3-methylsalicylaldehyde 
• 77-78-1 dimethyl sulfate 
• 33172-56-4 5-bromo-2-hydroxy-3-methyl benzaldehyde 
• 824-42-0 2-methoxy-3-methylbenzaldehyde 
• 5307-05-1 1-hydroxy-4-methoxy-2-methylbenzene 
• 5600-81-7 2-Hydroxy-5-methoxy-3-methylbenzylalkohol 
• 654-42-2 1,4-dihydroxy-2,6-dimethylbenzene 
• 95-48-7 ortho-cresol 
• 50848-60-7 2-bromo-6-methylbenzene-1,4-diol 
• 6293-55-6 2-bromo-6-methyl-[1,4]benzoquinone 
• 13523-12-1 1-bromo-2,5-dimethoxy-3-methylbenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 14538-50-2 1,3-dimethyl-2,5-dimethoxybenzene 

Downstream Products

• 5600-82-8 2,5-dimethoxy-3-methylphenylmethanol 
• 51983-88-1 4-(2,5-Dimethoxy-3-methylphenyl)butanoic Acid 
• 87050-76-8 (E)-1,2-bis<3-<(acetoxy)methyl>-2,5-dimethoxyphenyl>ethene 
• 72739-20-9 (+/-)-1-(2,5-dimethoxy-3-methylphenyl)-2-aminopropane 
• 87050-75-7 C₂₀H₂₂Br₂O₄ 
• 238739-95-2 2-chloromethyl-6-methyl-[1,4]benzoquinone 
• 87050-64-4 1-(chloromethyl)-2,5-dimethoxy-3-methylbenzene 
• 91893-83-3 Garcinoic acid 
• 22460-33-9 (E)-4-(2,5-dimethoxy-3-methylphenyl)butan-2-one 
• 866468-19-1 (2E,6E,10E)-(R)-16-(2,5-Dimethoxy-3-methyl-phenyl)-2,6,10,14-tetramethyl-14-triethylsilanyloxy-hexadeca-2,6,10-trienoic acid ethyl ester 
• 866468-21-5 (2E,6E,10E,14R)-ethyl 14-hydroxy-16-(2,5-dihydroxy-3-methylphenyl)-2,6,10,14-tetramethylhexadeca-2,6,10-trienoate 
• 866468-09-9 (2E,6E,10E,14R)-ethyl 14-hydroxy-16-(2,5-dimethoxy-3-methylphenyl)-2,6,10,14-tetramethylhexadeca-2,6,10-trienoate 
• 866468-11-3 (2E,6E,10E)-(R)-14-Hydroxy-2,6,10,14-tetramethyl-16-(5-methyl-3,6-dioxo-cyclohexa-1,4-dienyl)-hexadeca-2,6,10-trienoic acid ethyl ester 
• 866468-20-4 (2E,6E,10E,14R)-14-hydroxy-16-(2,5-dimethoxy-3-methylphenyl)-2,6,10,14-tetramethylhexadeca-2,6,10-trienoic acid 

Relevant academic research and scientific papers

A simple route to polysubstituted indoles exploiting azide induced furan ring opening

A straightforward, efficient indole synthesis based on thermolysis of 2-(2-azidobenzyl)furans with attack of the formed nitrene moiety onto the ipso position of furan ring has been developed. The cyclization is accompanied by furan ring opening and affords indoles with a 2-acylvinyl substituent suitable for further modifications.

A stereocontrolled synthesis of δ-trans-tocotrienoloic acid

(Chemical Equation Presented) A consise stereoselective total synthesis of a naturally occurring polymerase β inhibitor, δ-trans-tocotrienoloic acid (2), is described. The key step in the synthesis is an acid-catalyzed cyclodehydration reaction. Additiona

A convenient route for the synthesis of plumbagin

An efficient synthesis of plumbagin 1 has been carried out starting from 2, 6-dimethylbenzoquinone 4. Two of the key steps are: (1) prepared of aldehyde 2 and (ii) aromatization of 3 via conversion to enol acetate 7 followed by DDQ dehydrogenation to afford 8.

Serotonin receptor affinities of psychoactive phenalkylamine analogues

Employing a rat fundus model, the serotonin (5-HT) receptor affinities of 45 phenalkylamine analogues were determined. Phenethylamine and phenylisopropylamine possess relatively low receptor affinities; in general, mono-, di-, and trimethoxylation enhance affinity. Of the disubstituted compounds, methoxyl groups at the 2 and 5 positions are optimal for imparting a high affinity. 4-Methylation, 4-ethylation and 4-bromination also enhance receptor affinity, while N,N-dimethylation of the terminal amine decreases affinity. α-Methylation of phenethylamines has little effect on affinity when racemates are examined. Introduction of a benzylic keto group can either increase or decrease affinity, depending upon the presence of other aromatic substituents. The most behaviorally active compounds were found to possess the highest 5-HT receptor affinities, while less active compounds were found to possess lower affinities.