55486-60-7

Upstream product

• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 2687-12-9 cinnamyl chloride 
• 1811-58-1 1-cinnamyl-4-(2-hydroxyethyl)-piperazine 

Downstream Products

• 136744-06-4 3-(2-Chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1-{2-[4-((E)-3-phenyl-allyl)-piperazin-1-yl]-ethyl}-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride 

Relevant academic research and scientific papers

Studies on hypotensive agents. Synthesis of 1-substituted 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)- quinazolinediones

3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)- quinazolinedione was newly prepared. 1-Hydrogen atoms of the compound were variously substituted in order to test for their hypotensive activities on relaxing effects of the blood vessels. The compounds with 2-(1-pyrrolidinyl ethyl, 2-(1-piperidinyl)ethyl, 3-(dimethylamino)propyl, and 3-(N-benzyl-N-methylamino)propyl moieties showed significant activity. The 2-(1-piperidinyl)ethyl compound possessed activity approximately 23 times more potent than papaverine, however, it was less potent than cinnarizine.