555-25-9

Basic information

• Product Name: 4-(Acetylamino)-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
• Synonyms: 4-(Acetylamino)-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide;4-Acetylamino-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide;N-(2,4-Dimethoxypyrimidine-6-yl)-4-(acetylamino)benzenesulfonamide;N-[4-(2,6-Dimethoxy-4-pyrimidinylaminosulfonyl)phenyl]acetamide;N-[4-(2,6-Dimethoxy-4-pyrimidinylsulfamoyl)phenyl]acetamide;N4-Acetylsulphadimethoxine;SulfadiMethoxine N4-Acetate;Sulfadimethoxine EP Impurity B
• CAS NO: 555-25-9
• Molecular Formula: C₁₄H₁₆N₄O₅S
• Molecular Weight: 352.37
• Mol File: 555-25-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.3907 (rough estimate)
• Refractive Index: 1.6000 (estimate)
• Water Solubility: 0.19g/L(temperature not stated)
• CAS DataBase Reference: 4-(Acetylamino)-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Acetylamino)-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide(555-25-9)
• EPA Substance Registry System: 4-(Acetylamino)-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide(555-25-9)

Safety Data

• Hazardous Substances Data: 555-25-9(Hazardous Substances Data)

Usage

Uses

Sulfadimethoxine N4-Acetate (Sulfadimethoxine EP Impurity B) is a derivative of Sulfadimethoxine (S699060), a long-acting sulfonamide antibacterial that is frequently used in combination with Ormetoprim to prevent the spread of disease in freshwater aquaculture.

InChI:InChI=1/C14H16N4O5S/c1-9(19)15-10-4-6-11(7-5-10)24(20,21)18-12-8-13(22-2)17-14(16-12)23-3/h4-8H,1-3H3,(H,15,19)(H,16,17,18)

Upstream product

• 108-24-7 acetic anhydride 
• 3289-50-7 2,6-dimethoxypyrimidin-4-amine 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 

Downstream Products

• 122-11-2 sulfadimethoxine 

Relevant articles and documents

A sulfonamide - 2, 6 - dimethoxy pyrimidine preparation method (by machine translation)

The invention relates to a sulfonamide - 2, 6 - dimethoxy pyrimidine of the preparation method, the 4 - amino - 2, 6 - dimethoxy pyrimidine and P-acetyl amino sulfonyl chloride in N, N - dimethyl formamide and the presence of triethylamine, in the 15 - 20 °C reaction under 10 - 14 hours, then post-processed to obtain 4 - P-acetyl amino sulfonamide - 2, 6 - dimethoxy pyrimidine; will be 4 - P-acetyl amino sulfonamide - 2, 6 - dimethoxy pyrimidine in methanol and the mass concentration is 15% -25% of sodium hydroxide solution in the presence of, in 85 - 90 °C reaction 5 - 7 hours, then post-processed to obtain the sulfonamide - 2, 6 - dimethoxy pyrimidine. The invention the synthetic route and the optimization of the process conditions and the like, so that the realization of the kg sulfonamide - 2, 6 - dimethoxy pyrimidine at the time of preparation, sulfonamide - 2, 6 - dimethoxy pyrimidine yield and purity of the still very high, is suitable for industrial production. (by machine translation)