55514-11-9 Usage
Uses
Used in Research and Analytical Applications:
MALONIC ACID-2-13C is used as a research tool for studying metabolic pathways and enzyme mechanisms. The incorporation of the carbon-13 isotope allows for the tracking and analysis of the compound's behavior in biochemical processes, providing valuable insights into the underlying reactions and interactions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, MALONIC ACID-2-13C is used as a starting material or intermediate in the synthesis of various drugs and drug candidates. Its unique isotopic labeling can aid in the development of novel therapeutic agents with improved pharmacokinetic and pharmacodynamic properties.
Used in Competitive Inhibition Studies:
MALONIC ACID-2-13C is used as a competitive inhibitor for studying the function and inhibition of succinate dehydrogenase (complex II) in the respiratory electron transport chain. This application is particularly relevant in understanding the mechanisms of action of various drugs and toxins that target this enzyme complex.
Used in Biochemical Education:
As a classic example of a competitive inhibitor, MALONIC ACID-2-13C is employed in educational settings to demonstrate the principles of enzyme kinetics and the effects of inhibitors on enzyme activity. This helps students to better understand the fundamentals of biochemistry and the role of enzyme inhibition in drug action.
Check Digit Verification of cas no
The CAS Registry Mumber 55514-11-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,5,1 and 4 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 55514-11:
(7*5)+(6*5)+(5*5)+(4*1)+(3*4)+(2*1)+(1*1)=109
109 % 10 = 9
So 55514-11-9 is a valid CAS Registry Number.
InChI:InChI=1/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)/i1+1
55514-11-9Relevant academic research and scientific papers
Biosynthesis of Porphyrins and Related Macrocycles. Part 16. Proof that the Single Intramolecular Rearrangement leading to Natural Porphyrins (Type-III) occurs at the Tetrapyrrole Level
Battersby, Alan R.,Fookes, Christopher J. R.,Meegan, Mary J.,McDonald, Edward,Wurziger, Hanns K. W.
, p. 2786 - 2799 (2007/10/02)
The unrearranged aminomethylbilane (2) is synthesised by a rational route and is proved to be converted by the enzymes deaminase and cosynthetase, working co-operatively, into uro'gen-III (3).The single rearrangement step established earlier is thus proved to take place at the tetrapyrrole level.Synthesis of singly 13C-labelled bilane (2) followed by its enzymic conversion into uro'gen-III serves to register each of the pyrrole rings of the product relative to the initial bilane.Finally, methods for synthesis of the bilane are developed in two different doubly 13C-labelled forms to allow the following key points to be established largely by 13C n.m.r. spectroscopy: (a) as the bilane system is converted into uro'gen-III, intramolecular rearrangement of the terminal ring D occurs, and (b) the linear tetrapyrrole is converted intact into uro'gen-III.Syntheses of -, and -uroporphyrin octamethyl ester are described together with improved h.p.l.c. conditions for the separation of isomeric coproporphyrin tetramethyl esters.
