5552-80-7Relevant academic research and scientific papers
COMPOUNDS FOR THE TREATMENT OF CNS DISORDERS
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Page/Page column 48, (2012/05/20)
The invention relates to novel cycloalkyl- or cycloalkenyl-substituted pyrazolopyrimidinones of formula (I), wherein ā is selected from the group A1 consisting of a C3-C8-cycloalkyl group or a C4-C8-cycloalkenyl group, whereby the members of C3-C8-cycloalkyl group being selected from the group of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptanyl and cyclooctanyl; and the members of the C4-C8-cycloalkenyl group, being selected from cyclobutenyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, cyclooctenyl, cyclopentadienyl, cyclohexadienyl, cycloheptadienyl, cyclooctadienyl, cycloheptatrienyl, cyclooctathenyl, cyclooctatetraenyl. The new compounds shall be used for the manufacture of medicaments, in particular medicaments for improving perception, concentration, learning and/or memory in patients in need thereof. Chemically, the compounds are characterised as pyrazolopyrimidinones with a cycloalkyl-moiety directly bound to the 1 position of the pyrazolopyrimidinone and a second substituent in the 6 position which is bound via an optionally substituted methylene-bridge. Further aspects of the present invention refer to a process for the manufacture of the compounds and their use for producing medicaments.
PYRIDAZINE COMPOUND AND USE THEREOF
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Page/Page column 38, (2008/12/07)
A pyridazine compound of the formula: has an excellent plant disease controlling effect.
Syntheses and structure-activity relationship studies of piperidine-substituted quinolones as nonpeptide gonadotropin releasing hormone antagonists
Jiang, Jinlong,DeVita, Robert J.,Goulet, Mark T.,Wyvratt, Matthew J.,Lo, Jane-L.,Ren, Ning,Yudkovitz, Joel B.,Cui, Jisong,Yang, Yi T.,Cheng, Kang,Rohrer, Susan P.
, p. 1795 - 1798 (2007/10/03)
Syntheses and structure-activity relationships of piperidine-substituted quinolones as nonpeptide gonadotropin releasing hormone antagonists are described. Some of substituents on the piperidine ring that were investigated included a fused phenyl group, a
Reductive Amination of Ethynylpyridines with Sodium Cyanoborohydride
Sakamoto, Takao,Nagata, Hideo,Kondo, Yoshinori,Sato, Kaori,Yamanaka, Hiroshi
, p. 4866 - 4872 (2007/10/02)
In order to investigate the structure-activity relationship of betahistine derivatives, a general synthesis of methylated 2-(2-methylaminoethyl)pyridines was developed based on the addition of methylamine hydrochloride to methylated 2-ethynylpyridines under reductive conditions.In addition, the scope and limitations of the reductive addition were briefly examined.For example, the reaction proceeded smoothly with p-nitrophenylacetylene, whereas phenylacetylene itself did not react with methylamine.Keywords - ethynylpyridine; sodium cyanoborohydride; reductive amination; betahistine; palladium-catalyzed reaction; ethyl pyridineacetate; 2-(2-pyridyl)ethylamine
