55525-27-4

Usage

Uses

Used in Polymer Production:
Tetramethyl 1,1,2,3-Propanetetracarboxylate is used as a cross-linking agent to improve the physical and chemical properties of polymers, such as enhancing their thermal stability, tensile strength, and impact resistance.
Used in Organic Synthesis:
Tetramethyl 1,1,2,3-Propanetetracarboxylate is used as a reactant in the synthesis of other organic compounds, contributing to the development of various chemical products.
Used in Safety Considerations:
Although Tetramethyl 1,1,2,3-Propanetetracarboxylate is considered relatively safe for use and is not known to cause significant health hazards when handled and used properly, it should still be handled with care and in accordance with appropriate safety guidelines to ensure the well-being of individuals and the environment.

InChI:InChI=1/C11H16O8/c1-16-7(12)5-6(9(13)17-2)8(10(14)18-3)11(15)19-4/h6,8H,5H2,1-4H3

Upstream product

• 5202-32-4 5-methoxy-furan-2,3,4-tricarboxylic acid trimethyl ester 
• 624-48-6 dimethyl cis-but-2-ene-1,4-dioate 
• 108-59-8 malonic acid dimethyl ester 
• 624-49-7 dimethylfumarate 
• 18424-76-5 dimethyl malonate sodium salt 

Downstream Products

• 99-14-9 tricarallylic acid 

Relevant academic research and scientific papers

Chiral bicyclic guanidines: A concise and efficient aziridine-based synthesis

A series of chiral bicyclic guanidines, either symmetrical or non-symmetrical, was synthesized using a concise and efficient aziridine-based synthetic methodology. Starting from commercial amino alcohols, five synthetic steps were performed, with only thr

Michael reaction of stabilized carbon nucleophiles catalyzed by [RuH2(PPh3)4]

The Michael reaction of active methylene compounds lacking cyano groups such as malonates, β-ketoesters, 1,3-diketones, 1,1-disulfones, nitrocompounds, Meldrum acid, and anthrone with common acceptors proceeds in acetonitrile solution in the presence of [RuH2(PPh3)4] as the catalyst. Cyano acetates, more acidic than malonates in organic solvents, are also excellent substrates for this reaction. In a number of cases, intramolecular aldol reactions catalyzed by [RuH2(PPh3)4] were also observed as side reactions. Catalysis by other ruthenium and rhodium complexes has been examined. Selectivity studies performed with malonate and disulfone donors indicate that the catalyst selectively activates Michael donors that can coordinate with ruthenium(II). Additionally, it has been shown that the reaction requires the presence of free phosphine. Therefore, the Michael reaction of stabilized enolates appears to be a ruthenium- and phosphine-catalyzed reaction. From a practical point of view, the use of readily prepared [RuH2(PPh3)4] as the catalyst in acetonitrile provided the best solution for the Michael reaction of active methylene compounds.

Preparation of aconitic acid

Novel methods for preparing polycarboxylic compounds which are useful as metal sequestrants and food acidulants are disclosed. These compounds are aconitic and a mixture of aconitic acid, and the lactones of isocitric acid and alloisocitric acid. The compounds can be neutralized to the corresponding salts which, in turn, are metal sequestering agents. The novel methods include chlorination of propane-1,1,2,3-tetracarboxyalic tetraesters.

Process for preparing isocitric acid, alloisocitric acid and lactones thereof

Novel methods for preparing polycarboxylic compounds which are useful as metal sequestrants and food acidulants are disclosed. These compounds, isocitric acid, alloisocitric acid and lactones thereof, can also be neutralized to the corresponding salts, which in turn are metal sequestering agents. The novel methods for the preparation of these compounds include halogenation of propane 1,1,2,3-tetracarboxylic acid or its salts and/or the tetraester of the acid with subsequent formation of isocitric acid, alloisocitric acid and their lactones under specified pH conditions.