55536-40-8

Upstream product

• 40534-52-9 N-(4-fluorobenzyl)isatoic anhydride 
• 14527-26-5 2-methylisothiourea sulphate 
• 110-16-7 maleic acid 
• 420-04-2 CYANAMID 
• 1040308-57-3 N-(4-fluorobenzyl)-2-iodoaniline 
• 13939-06-5 molybdenum hexacarbonyl 
• 615-43-0 2-iodophenylamine 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 60012-25-1 1-(4-fluoro-benzyl)-2-imino-3-methyl-2,3-dihydro-1H-quinazolin-4-one 

Relevant academic research and scientific papers

Synthesis of 2-Aminoquinazolinones via Carbonylative Coupling of ortho-Iodoanilines and Cyanamide

Herein, we describe a convenient and efficient synthesis of 2-aminoquinazolin-4(3H)-ones and N1-substituted 2-aminoquinazolin-4(1H)-ones by a domino carbonylation/cyclization process. The reaction proceeds via carbonylative coupling of readily available ortho-iodoanilines with cyanamide followed by in situ ring closure of an N-cyanobenzamide intermediate. The products were easily isolated by precipitation in moderate to excellent yields for a wide range of substrates, making this a highly attractive method for the synthesis of 2-aminoquinazolinones.

1-Substituted-2-imino-quinazolin-4(1H)ones

Anti-Histaminics of the formula SPC1 Wherein R1 is alkyl, alkenyl or phenalkyl, R2 and R3 are hydrogen, alkyl or alkenyl and R and R' are optional are prepared by reacting a 1-substituted isatoic anhydride with a S-methyl-