55544-63-3Relevant academic research and scientific papers
6-(Alkylamino)-9-benzyl-9H-purines. A New Class of Anticonvulsant Agents
Kelley, James L.,Krochmal, Mark P.,Linn, James A.,McLean, Ed W.,Soroko, Francis E.
, p. 606 - 612 (2007/10/02)
Several 9-alkyl-6-substituted-purines were synthesized and tested for anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats.Most compounds were prepared in three steps from 5-amino-4,6-dichloropyrimidine or in two steps via alkylation of 6-chloropurine.Potent anticonvulsant activity against MES resided in compounds that contain a benzyl substituent at the 9-position of 6-(methylamino)- or 6-(dimethylamino)purine.Among commonly used agents for control of seizures, this type of structure represents a new class of potent anticonvulsant agents.
5-Amino-4-chloro-6-(substituted amino)-pyrimidines
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, (2008/06/13)
The present invention relates to compounds having the following formula: SPC1 In which R2 is naphthyl alkyl of 1 to 3 carbons or phenyl alkyl of 1 to 3 carbons substituted in the aryl moiety by one or two alkoxy of 1 to 6 carbons, or one or two
