55544-80-4

Upstream product

• 102-49-8 3,4-dichlorobenzyl amine 
• 87-42-3 6-chloropurine 
• 55544-63-3 6-chloro-N⁴-(3,4-dichloro-benzyl)-pyrimidine-4,5-diamine 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 112089-16-4 [9-(3,4-Dichloro-benzyl)-9H-purin-6-yl]-dimethyl-amine 
• 1246307-46-9 8-bromo-6-chloro-9-[(3,4-dichlorophenyl)methyl]-9H-purine 

Relevant academic research and scientific papers

Purine compounds

The invention provides an antimycobacterial 6-aryl-9-(m- or p-substituted-benzyl) purine and purine analog compounds.

Synthesis, biological activity, and SAR of antimycobacterial 9-aryl-, 9-arylsulfonyl-, and 9-benzyl-6-(2-furyl)purines

9-Aryl-, 9-arylsulfonyl- and 9-benzyl-6-(2-furyl)purines were synthesized by N-alkylation or N-arylation of the purine followed by Stille coupling to introduce the furyl substituent in the 6-position and the compounds screened for activity against Mycobac

6-(Alkylamino)-9-benzyl-9H-purines. A New Class of Anticonvulsant Agents

Several 9-alkyl-6-substituted-purines were synthesized and tested for anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats.Most compounds were prepared in three steps from 5-amino-4,6-dichloropyrimidine or in two steps via alkylation of 6-chloropurine.Potent anticonvulsant activity against MES resided in compounds that contain a benzyl substituent at the 9-position of 6-(methylamino)- or 6-(dimethylamino)purine.Among commonly used agents for control of seizures, this type of structure represents a new class of potent anticonvulsant agents.

5-Amino-4-chloro-6-(substituted amino)-pyrimidines

The present invention relates to compounds having the following formula: SPC1 In which R2 is naphthyl alkyl of 1 to 3 carbons or phenyl alkyl of 1 to 3 carbons substituted in the aryl moiety by one or two alkoxy of 1 to 6 carbons, or one or two