55559-54-1

Upstream product

• 90318-68-6 1-(2',3',5'-Tri-O-acetyl-β-D-ribofuranosyl)-3-thiocarbamoyl-4-methylmercaptopyrazolo<3,4-d>pyrimidine 
• 54385-49-8 5-amino-1H-pyrazole-3,4-dicarbonitrile 
• 84941-17-3 3,4-Dicyano-5-ethoxymethyleneaminopyrazole 
• 80117-79-9 3-Cyano-4-methylmercaptopyrazolo<3,4-d>pyrimidine 
• 80117-80-2 1-(2',3',5'-Tri-O-acetyl-β-D-ribofuranosyl)-3-cyano-4-methylmercaptopyrazolo<3,4-d>pyrimidine 
• 82859-58-3 3-Cyano-4-mercaptopyrazolo<3,4-d>pyrimidine 

Relevant academic research and scientific papers

SYNTHESIS OF 3-SUBSTITUTED 4-METHYLMERCAPTO- AND 4-AMINOPYRAZOLOPYRIMIDINES AND THEIR RIBOSIDES

3-Cyano-4-methylmercaptopyrazolopyrimidine, fusion of which with 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose gave its per-O-acetylated 1-β-D-ribofuranoside in 61percent yield, was synthesized from 3,4-dicyano-5-aminopyrazole.O-Deacetylation of the per-O-acetylated 1-β-D-ribofuranoside was carried out by the action of 1percent HCl in methanol. New pyrazolopyrimidines were obtained by the reaction of 3-cyano-4-methylmercaptopyrazolopyrimidine and its 1-riboside, as well as 3-cyano-4-aminopyrazolopyrimidine, with a number of nucleophilic reagents.The cytotoxic activities of the compounds obtained were studied.

7-Substituted nucleoside compounds

Novel compounds of the formula SPC1 Wherein R is selected from the group consisting of carboxamidine, carboxylic acid, carboxamide, methyl formimidate, thiocarboxamide, carboxamidoxime, carboxamidrazone, and cyano. The compounds have been demonstrated to be useful by having a degree of antimetabolic activity.