54385-49-8

Basic information

• Product Name: 3-amino-1H-pyrazole-4,5-dicarbonitrile
• Synonyms: 3-amino-1H-pyrazole-4,5-dicarbonitrile;1H-Pyrazole-3,4-dicarbonitrile, 5-amino-;3-Aminopyrazole-4,5-dicarbonitrile;5-amino-1H-pyrazole-3,4-dicarbonitrile
• CAS NO: 54385-49-8
• Molecular Formula: C₅H₃N₅
• Molecular Weight: 133.11
• Product Categories: API intermediates
• Mol File: 54385-49-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 626.742 °C at 760 mmHg
• Flash Point: 332.842 °C
• Appearance: /
• Density: 1.549 g/cm³
• Vapor Pressure: 1.27E-15mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 7.10±0.50(Predicted)
• CAS DataBase Reference: 3-amino-1H-pyrazole-4,5-dicarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-1H-pyrazole-4,5-dicarbonitrile(54385-49-8)
• EPA Substance Registry System: 3-amino-1H-pyrazole-4,5-dicarbonitrile(54385-49-8)

Safety Data

• Hazardous Substances Data: 54385-49-8(Hazardous Substances Data)

Usage

General Description

3-Amino-1H-pyrazole-4,5-dicarbonitrile is a chemical compound with the molecular formula C5H3N7. It is a white to yellow crystalline powder that is soluble in water. 3-Amino-1H-pyrazole-4,5-dicarbonitrile is used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical drugs. It has also been studied for its potential biological and pharmacological properties, including antiparasitic, anti-inflammatory, and antiviral activities. 3-Amino-1H-pyrazole-4,5-dicarbonitrile is a versatile intermediate in organic synthesis and has also been used in the development of novel materials and catalysts.

InChI:InChI=1/C5H3N5/c6-1-3-4(2-7)9-10-5(3)8/h(H3,8,9,10)

Upstream product

• 870-46-2 t-butoxycarbonylhydrazine 
• 670-54-2 ethenetetracarbonitrile 
• 5745-84-6 5-amino-3,4-dicyano-pyrazole-1-carboxylic acid amide 

Downstream Products

• 6826-96-6 4-amino-3-cyano-pyrazolo<3,4-d>pyrimidine 
• 80117-79-9 3-Cyano-4-methylmercaptopyrazolo<3,4-d>pyrimidine 
• 90213-39-1 2-(2',3',5'-Tri-O-acetyl-β-D-ribofuranosyl)-3-cyano-4-methylmercaptopyrazolo<3,4-d>pyrimidine 
• 80117-80-2 1-(2',3',5'-Tri-O-acetyl-β-D-ribofuranosyl)-3-cyano-4-methylmercaptopyrazolo<3,4-d>pyrimidine 
• 90318-68-6 1-(2',3',5'-Tri-O-acetyl-β-D-ribofuranosyl)-3-thiocarbamoyl-4-methylmercaptopyrazolo<3,4-d>pyrimidine 
• 80117-82-4 1-(β-D-Ribofuranosyl)-3-thiocarbamoyl-4-methylmercaptopyrazolo<3,4-d>parimidine 
• 80117-81-3 1-(β-D-Ribofuranosyl)-3-cyano-4-methylmercaptopyrazolo<3,4-d>pyrimidine 
• 82859-59-4 4-Hydrazinopyrazolo<3,4-d>pyrimidine-3-carboxylic Acid Iminohydrazide 
• 90213-35-7 3-Thiocarbamoyl-4-methylmercaptopyrazolo<3,4-d>pyrimidine 
• 82859-58-3 3-Cyano-4-mercaptopyrazolo<3,4-d>pyrimidine 

Relevant articles and documents

ATG7 INHIBITORS AND THE USES THEREOF

Disclosed are chemical entities which are compounds of formula (I) : or a pharmaceutically acceptable salt thereof, wherein R1, R2, and Ra have the values described herein. Chemical entities according to the disclosure can be useful as inhibitors of ATG7. Further provided are pharmaceutical compositions comprising a chemical entity of the disclosure and methods of using the compositions in the treatment of cancer.

6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof

Novel 6-heterocyclyl-pyrazolo[3,4-d]pyrimidin-4-ones, useful in treating cardiovascular disease, are prepared by reacting a 5-amino-1H-pyrazole-4-carboxamide with heterocyclylcarboxaldehyde or by reacting a 5-amino-1H-pyrazole-4-carbonitrile with a heterocyclylcarboxamidine, followed by diazotization and hydrolysis of the resulting 4-amino-6-heterocyclyl-pyrazolo[3,4-d]pyrimidine.