55579-77-6

Usage

Uses

Used in Pharmaceutical Industry:
5-(2-Methoxy-phenyl)-cyclohexane-1,3-dione is used as a building block for the production of various drugs, particularly anti-inflammatory and anti-cancer agents. Its chemical structure allows for the development of compounds that can effectively target and treat inflammation and cancer cells.
Used in Agrochemical Industry:
In addition to its pharmaceutical applications, 5-(2-Methoxy-phenyl)-cyclohexane-1,3-dione is also utilized in the synthesis of certain pesticide and herbicide compounds. Its versatility as a chemical intermediate enables the creation of effective agents for controlling pests and unwanted plant growth in agricultural settings.
Overall, 5-(2-Methoxy-phenyl)-cyclohexane-1,3-dione's industrial applications are diverse, owing to its adaptability as a chemical intermediate in both the pharmaceutical and agrochemical sectors. Its ability to contribute to the development of drugs and agrochemicals that address significant health and agricultural challenges underscores its importance in these industries.

InChI:InChI=1/C13H14O3/c1-16-13-5-3-2-4-12(13)9-6-10(14)8-11(15)7-9/h2-5,9H,6-8H2,1H3

Upstream product

• 95486-40-1 2-<2-Methoxy-phenyl>-4,6-dioxo-cyclohexan-1,3-dicarbonsaeure-diethylester 
• 105-53-3 diethyl malonate 
• 135-02-4 ortho-anisaldehyde 
• 60438-50-8 2-methoxybenzalacetone 
• 6768-22-5 diethyl 2-methoxybenzylidenemalonate 

Downstream Products

• 55579-56-1 7-chloro-10-hydroxy-3-(2-methoxy-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione 
• 239130-93-9 7-(2-methoxyphenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one 
• 144128-63-2 7-Chloro-1-[(E)-3-dimethylamino-propylimino]-10-hydroxy-3-(2-methoxy-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 144155-40-8 7-Chloro-1-[(E)-3-dimethylamino-propylimino]-3-(2-methoxy-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 144155-06-6 7-Chloro-3-(2-methoxy-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione 

Relevant academic research and scientific papers

Construction of Multiple-Substituted Chiral Cyclohexanes through Hydrogenative Desymmetrization of 2,2,5-Trisubstituted 1,3-Cyclohexanediones

The construction of chiral multiple-substituted cyclohexanes motifs is a challenging topic in organic synthesis. By the combination of desymmetrization and remote stereocontrol, a ruthenium-catalyzed transfer hydrogenative desymmetrization of 2,2,5-trisubstituted 1,3-cyclohexanediones has been successfully developed for the construction of chiral multiple-substituted cyclohexanes with high enantioselectivity and diastereoselectivity. When an ester group was introduced to the two-position, a hydrogenative desymmetrization/transesterification cascade occurred, affording the bicyclic lactones bearing three stereocenters, including two discrete stereocenters and one quaternary stereogenic center, with high enantioselectivity. The products are the multiple-substituted chiral cyclohexanes bearing the hydroxyl and carbonyl functional groups, which provide a new opportunity for further precise elaboration.

QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS

Compounds of general formula (I); or a stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof, wherein R1, R2, R3, R4, R5, R6, R8 and R9 are as defined herein, are useful for the treatment of diseases and conditions which are mediated by excessive or inappropriate Hsp90 activity such as cancers, viral infection and inflammatory diseases or conditions.

PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE CYCLIC ENAMINONE DERIVATIVES

A process for the production of optically active cyclic enaminone derivatives characterized by aminating one of the carbonyl groups of a cyclic 1,3-diketone derivative having a symmetry plane to obtain an optically isomeric mixture of chiral cyclic enamin

Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures

To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates.Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained.The imino derivative of7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.