55581-63-0

Usage

Chemical structure

1-(2-Nitrobenzyl)pyrrolidine is a chemical compound consisting of a pyrrolidine ring with a 2-nitrobenzyl group attached to it.

Pyrrolidine ring

The pyrrolidine ring contains four carbon atoms and one nitrogen atom.

2-Nitrobenzyl group

The 2-nitrobenzyl group consists of a benzene ring with a nitro group attached to the carbon in the 2-position.

Application in organic synthesis

1-(2-Nitrobenzyl)pyrrolidine is commonly used in organic synthesis as a building block for the preparation of various molecules and pharmaceuticals.

Potential biological activities

The compound possesses potential biological activities and may be used in medicinal chemistry for drug development.

Chemical manipulation

The nitro group in the 2-nitrobenzyl moiety can be chemically manipulated to yield different derivatives of the compound with varied properties and applications.

InChI:InChI=1/C11H14N2O2/c14-13(15)11-6-2-1-5-10(11)9-12-7-3-4-8-12/h1-2,5-6H,3-4,7-9H2

Upstream product

• 123-75-1 pyrrolidine 
• 612-23-7 2-nitrobenzyl chloride 
• 3958-60-9 2-nitrophenylmethyl bromide 

Downstream Products

• 55727-59-8 2-(pyrrolidin-1-ylmethyl)benzenamine 
• 1334322-60-9 N-carbomethoxy-N-methoxy-(2-chloromethyl)-aniline 
• 1334322-44-9 N-carbomethoxy-N-hydroxy-(2-pyrrolidinomethyl)-aniline 
• 1334322-42-7 N-hydroxy-(2-pyrrolidinomethyl)-aniline 
• 1334322-46-1 N-carbomethoxy-N-methoxy-(2-pyrrolidinomethyl)-aniline 
• 175013-18-0 pyraclostrobin 

Relevant academic research and scientific papers

N-Carbomethoxy-N-methoxy-(2-chloromethyl)-anilines, their preparation and their use as precursors for preparing 2-(pyrazol-3'-yloxymethylene)-anilides

The present invention relates to N-carbomethoxy-N-methoxy-(2-chloromethyl)-aniline compounds of the formula I, wherein: n is 0, 1, 2 or 3, each R1 is independently selected from halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy. The invention also relates to processes and intermediates for preparing such compounds of formula I. The invention furthermore relates to processes for preparing 2-(pyrazol-3′-yloxymethylene)-anilides in which compounds of formula I are applied as precursors.

N-CARBOMETHOXY-N-METHOXY-(2-CHLOROMETHYL)-ANILINES, THEIR PREPARATION AND THEIR USE AS PRECURSORS FOR PREPARING 2-(PYRAZOL-3'-YLOXYMETHYLENE)-ANILIDES

The present invention relates to N-carbomethoxy-N-methoxy-(2-chloromethyl)-aniline compounds of the formula I, wherein: n is 0, 1, 2 or 3, each R1 is independently selected from halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4- alkoxy or C1-C4-haloalkoxy. The invention also relates to processes and intermediates for preparing such compounds of formula I. The invention furthermore relates to processes for preparing 2-(pyrazol-3'-yloxymethylene)-anilides in which compounds of formula I are applied as precursors.

A fast and highly efficient method for the synthesis of tertiary amines in aqueous medium

A facile and highly efficient method for the synthesis of tertiary amines by the reaction of secondary amines with benzylic bromides and 1,1'-dibromo p/o-xylenes in aqueous dioxane and NaOH is described. The reactions are dually promoted by the base in short time (15 min.) at ambient conditions in aqueous medium.