556039-60-2Relevant academic research and scientific papers
A short total synthesis of the alkaloids piperolactam C, goniopedaline, and stigmalactam
Rys, Veronique,Couture, Axel,Deniau, Eric,Grandclaudon, Pierre
, p. 1231 - 1237 (2007/10/03)
The total synthesis of the polyalkoxylated alkaloids piperolactam C, goniopedaline and stigmalactam by combinatorial metalation/cyclization strategies has been achieved. The synthetic route involved the preliminary construction of the polyalkoxylated isoindolinone template by Parham's technique. Benzylic lactam deprotonation allowed connection of a hydroxybenzyl appendage, and the synthesis of the target natural products was completed by subsequent E1cB elimination, radical cyclization and final deprotection. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
