556112-21-1

Basic information

• Product Name: 2,5-dichloro-1-trifluoromethanesulfonyloxybenzene
• Synonyms: 2,5-dichloro-1-trifluoromethanesulfonyloxybenzene
• CAS NO: 556112-21-1
• Molecular Weight: 295.066
• Mol File: 556112-21-1.mol

Chemical Properties

• CAS DataBase Reference: 2,5-dichloro-1-trifluoromethanesulfonyloxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dichloro-1-trifluoromethanesulfonyloxybenzene(556112-21-1)
• EPA Substance Registry System: 2,5-dichloro-1-trifluoromethanesulfonyloxybenzene(556112-21-1)

Safety Data

• Hazardous Substances Data: 556112-21-1(Hazardous Substances Data)

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 583-78-8 2,5-dichlorophenol 

Downstream Products

• 556112-22-2 2-(2,5-dichlorophenyl)trimethylsilylacetylene 
• 38417-89-9 (2,5-dichlorophenyl)acetylene 
• 1043912-28-2 2,5-dichloro-6-trifluoromethanesulfonylphenol 

Relevant articles and documents

Novel 3-phenylprop-2-ynylamines as inhibitors of mammalian squalene epoxidase.

The synthesis of a novel series of 3-phenylprop-2-ynylamines as selective mammalian squalene epoxidase inhibitors is described. Structure activity relationship studies led to the discovery of compound 19, 1-[3-(3,5-dichlorophenyl)-prop-2-ynyl]-3- methylpiperidine hydrochloride with an IC50 of 2.8 +/- 0.6 microM against rat liver squalene epoxidase. Against 23 strains of fungal squalene epoxidase compound 19 was found to be inactive.

Decoupling deprotonation from metalation: Thia-fries rearrangement

(Chemical Equation Presented) Label-enabled: Studies with 2H-, 18O-, and 34S-labeled aryl triflates show that lithium diisopropylamide-mediated thia-Fries rearrangement proceeds through an irreversible ortho deprotonation (see scheme; DIPA = diisopropylamine, LDA = lithium diisopropylamide). In contrast, ortho metalation results exclusively in the generation of a benzyne.