38417-89-9

Basic information

• Product Name: 1,4-DICHLORO-2-ETHYNYL-BENZENE
• Synonyms: 1,4-DICHLORO-2-ETHYNYL-BENZENE;Benzene, 1,4-dichloro-2-ethynyl-
• CAS NO: 38417-89-9
• Molecular Formula: C₈H₄Cl₂
• Molecular Weight: 171.02336
• Mol File: 38417-89-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,4-DICHLORO-2-ETHYNYL-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-DICHLORO-2-ETHYNYL-BENZENE(38417-89-9)
• EPA Substance Registry System: 1,4-DICHLORO-2-ETHYNYL-BENZENE(38417-89-9)

Safety Data

• Hazardous Substances Data: 38417-89-9(Hazardous Substances Data)

Usage

General Description

1,4-Dichloro-2-ethynyl-benzene is a chemical compound with the molecular formula C8H4Cl2. It is a colorless liquid with a benzene-like odor. 1,4-Dichloro-2-ethynyl-benzene is primarily used as an intermediate in the production of pharmaceuticals and agrochemicals. It is also utilized in the synthesis of various organic compounds, such as dyes and pesticides. 1,4-Dichloro-2-ethynyl-benzene is considered to be a hazardous material and should be handled with care due to its toxic and irritant properties. It is important to follow proper safety precautions when working with this chemical substance.

Upstream product

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Downstream Products

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Relevant articles and documents

A copper (II) (II) composite chlorinating agent and copper-based composite chlorinating agent synthesis of 1-chloro-2-aryl acetylene method

The invention discloses a copper (II) composite chlorinating agent and a method for synthesizing 1-chlorine-2-aryl acetylene based on the copper (II) composite chlorinating agent. The structural formula of the copper (II) composite chlorinating agent is CuCl2.xNaCl.yAl2O3. The chlorinating agent is applicable to chlorination of various substituted aryl acetylene substrates, and is high in universality; the chlorinating agent can directly carry out chlorination reaction on aryl acetylene so as to obtain a 1-chlorine-2-aryl acetylene product; the method is mild in reaction condition, 1-chlorine-2-aryl acetylene can be synthesized with high yield and high selectivity, and the production cost of the 1-chlorine-2-aryl acetylene derivative is greatly lowered.

Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition

Indoleamine 2,3-dioxygenase 1 (IDO1) is an important therapeutic target for the treatment of diseases such as cancer that involve pathological immune escape. Starting from the scaffold of our previously discovered IDO1 inhibitor 4-phenyl-1,2,3-triazole, we used computational structure-based methods to design more potent ligands. This approach yielded highly efficient low molecular weight inhibitors, the most active being of nanomolar potency both in an enzymatic and in a cellular assay, while showing no cellular toxicity and a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO). A quantitative structure-activity relationship based on the electrostatic ligand-protein interactions in the docked binding modes and on the quantum chemically derived charges of the triazole ring demonstrated a good explanatory power for the observed activities.

An approach to the synthesis of unsymmetrically substituted chlorobiphenyls

The Diels-Alder cycloaddition of o-chloranil with phenylacetylenes substituted with chlorine in the ring can afford chlorobiphenyls upon photodecomposition of the brodged diketone adduct.Biphenyls derived from 3-chloro-, 4-chloro-, 2,4-dichloro-, and (2,5