38417-89-9

Usage

Uses

Used in Pharmaceutical Industry:
1,4-Dichloro-2-ethynyl-benzene is used as a chemical intermediate for the production of pharmaceuticals, contributing to the development of new drugs and medicines.
Used in Agrochemical Industry:
In the agrochemical sector, 1,4-Dichloro-2-ethynyl-benzene serves as a precursor in the synthesis of agrochemicals, aiding in the creation of products that protect crops and enhance agricultural yields.
Used in Dye Industry:
1,4-Dichloro-2-ethynyl-benzene is utilized as a starting material in the synthesis of dyes, playing a crucial role in the production of colorants for various applications.
Used in Pesticide Industry:
This chemical compound is also employed as an intermediate in the manufacturing of pesticides, helping to develop effective solutions for pest control in agriculture and other industries.
Safety Precautions:
Given its toxic and irritant properties, 1,4-Dichloro-2-ethynyl-benzene is classified as a hazardous material. It is imperative to handle this chemical with care and adhere to proper safety measures to minimize risks to health and the environment.

Upstream product

• 29682-41-5 2,5-dichloroiodobenzene 
• 2476-37-1 2,5-dichloroacetophenone 
• 556112-21-1 2,5-dichloro-1-trifluoromethanesulfonyloxybenzene 
• 583-78-8 2,5-dichlorophenol 
• 556112-22-2 2-(2,5-dichlorophenyl)trimethylsilylacetylene 

Downstream Products

• 75717-74-7 1,4,5,6-tetrachloro-7-(2,5-dichlorophenyl)bicyclo<2.2.2>-octa-5,7-diene-2,3-dione 
• 1378976-05-6 4-(2,5-dichlorophenyl)-1H-1,2,3-triazole 
• 1475-12-3 1-(2,5-dichlorophenyl)ethanol 
• 2476-37-1 2,5-dichloroacetophenone 

Relevant academic research and scientific papers

A copper (II) (II) composite chlorinating agent and copper-based composite chlorinating agent synthesis of 1-chloro-2-aryl acetylene method

The invention discloses a copper (II) composite chlorinating agent and a method for synthesizing 1-chlorine-2-aryl acetylene based on the copper (II) composite chlorinating agent. The structural formula of the copper (II) composite chlorinating agent is CuCl2.xNaCl.yAl2O3. The chlorinating agent is applicable to chlorination of various substituted aryl acetylene substrates, and is high in universality; the chlorinating agent can directly carry out chlorination reaction on aryl acetylene so as to obtain a 1-chlorine-2-aryl acetylene product; the method is mild in reaction condition, 1-chlorine-2-aryl acetylene can be synthesized with high yield and high selectivity, and the production cost of the 1-chlorine-2-aryl acetylene derivative is greatly lowered.

TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS

The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.

Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition

Indoleamine 2,3-dioxygenase 1 (IDO1) is an important therapeutic target for the treatment of diseases such as cancer that involve pathological immune escape. Starting from the scaffold of our previously discovered IDO1 inhibitor 4-phenyl-1,2,3-triazole, we used computational structure-based methods to design more potent ligands. This approach yielded highly efficient low molecular weight inhibitors, the most active being of nanomolar potency both in an enzymatic and in a cellular assay, while showing no cellular toxicity and a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO). A quantitative structure-activity relationship based on the electrostatic ligand-protein interactions in the docked binding modes and on the quantum chemically derived charges of the triazole ring demonstrated a good explanatory power for the observed activities.

Novel 3-phenylprop-2-ynylamines as inhibitors of mammalian squalene epoxidase.

The synthesis of a novel series of 3-phenylprop-2-ynylamines as selective mammalian squalene epoxidase inhibitors is described. Structure activity relationship studies led to the discovery of compound 19, 1-[3-(3,5-dichlorophenyl)-prop-2-ynyl]-3- methylpiperidine hydrochloride with an IC50 of 2.8 +/- 0.6 microM against rat liver squalene epoxidase. Against 23 strains of fungal squalene epoxidase compound 19 was found to be inactive.

An approach to the synthesis of unsymmetrically substituted chlorobiphenyls

The Diels-Alder cycloaddition of o-chloranil with phenylacetylenes substituted with chlorine in the ring can afford chlorobiphenyls upon photodecomposition of the brodged diketone adduct.Biphenyls derived from 3-chloro-, 4-chloro-, 2,4-dichloro-, and (2,5