55625-99-5Relevant academic research and scientific papers
NICKELAVERBINDUNGEN ALS ZWISCHENKOMPLEXE DER -CYCLOADDITION VON ALKINEN MIT ISOCYANATEN ZU 2-PYRIDONEN
Hoberg, Heinz,Oster, Benno W.
, p. 359 - 364 (1983)
Diphenylacetylene and phenylisocyanate react with TMEDA/Ni0 to give an azanickela-5-ring (IVa) which yields the azanickela-7-ring (IIb) with an activated alkyne.It is shown that both IVa and IIb are intrmediates in the nickel-catalysed 2-pyridone synthesis.Pyrimidinediones are formed from diphenylacetylene and alkylisocyanates with TMEDA/Ni0.
Regioselective arylation of uracil and 4-pyridone derivatives via copper(I) bromide mediated C-H bond activation
Cheng, Chien,Shih, Yu-Chiao,Chen, Hui-Ting,Chien, Tun-Cheng
, p. 1387 - 1396 (2013/02/23)
A facile and effective synthesis of 6-aryluracil derivatives was accomplished by the direct C-H bond activation for arylation. A series of 6-aryl-1,3-dimethyluracils were synthesized from the reaction of 1,3-dimethyluracil with various phenyl iodides in DMF, in the presence of copper(I) bromide as the catalyst and lithium tert-butoxide as the base. This methodology is applicable to a variety of 5-substituted uracils as well as 4-pyridone to provide direct accesses to versatile uracil and 4-pyridone derivatives.
