55655-84-0

Basic information

• Product Name: 1-(3-TRIFLUOROMETHYL-PHENYL)-BUTANE-1,3-DIONE
• Synonyms: 1-(3-TRIFLUOROMETHYL-PHENYL)-BUTANE-1,3-DIONE
• CAS NO: 55655-84-0
• Molecular Formula: C11H9F3O2
• Molecular Weight: 230.18
• Mol File: 55655-84-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 257.1°C at 760 mmHg
• Flash Point: 88.8°C
• Appearance: /
• Density: 1.246g/cm³
• Vapor Pressure: 0.0148mmHg at 25°C
• Refractive Index: 1.459
• PKA: 8.06±0.10(Predicted)
• CAS DataBase Reference: 1-(3-TRIFLUOROMETHYL-PHENYL)-BUTANE-1,3-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-TRIFLUOROMETHYL-PHENYL)-BUTANE-1,3-DIONE(55655-84-0)
• EPA Substance Registry System: 1-(3-TRIFLUOROMETHYL-PHENYL)-BUTANE-1,3-DIONE(55655-84-0)

Safety Data

• Hazardous Substances Data: 55655-84-0(Hazardous Substances Data)

Usage

General Description

1-(3-trifluoromethyl-phenyl)-butane-1,3-dione is a chemical compound that is commonly used in the field of organic chemistry. It is a yellow, crystalline powder with a molecular formula of C10H9F3O2. 1-(3-TRIFLUOROMETHYL-PHENYL)-BUTANE-1,3-DIONE is widely used as a reagent in various chemical reactions, such as the synthesis of pharmaceuticals and agrochemicals. It has a strong electron-withdrawing group, the trifluoromethyl group, which makes it a versatile building block in organic synthesis. Its unique structure and properties make it an important compound in the development of new materials and active pharmaceutical ingredients.

InChI:InChI=1/C11H9F3O2/c1-7(15)5-10(16)8-3-2-4-9(6-8)11(12,13)14/h2-4,6H,5H2,1H3

Upstream product

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Relevant articles and documents

2-(1H-Pyrazol-1-yl)acetic acids as chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTh2) antagonists

In this manuscript, the synthesis and biological activity of a series of pyrazole acetic acid derivatives as CRTh2 antagonists is presented. Biological evaluation in vitro revealed that the pyrazole core showed in several cases a different structure-activity relationship (SAR) to that of related indole acetic acid. A potent series of ortho-sulfonyl benzyl substituents was found, from which compounds 27 and 63 were advanced to in vivo profiling.

Formation of functionalized 2H-azirines through phio-mediated trifluoroethoxylation and azirination of enamines

A variety of enaminones and enamine carboxylic esters were converted to trifluoroethoxylated 2H-azirines through reactions with PhIO in trifluoroethanol (TFE). The cascade reaction is postulated to proceed via a PhIO-mediated oxidative trifluoroethoxylation and a subsequent azirination of the α-trifluoroethoxylated enamine intermediates.