55667-42-0

Upstream product

• 142327-37-5 3-(phenylsulfanyl)benzaldehyde 

Downstream Products

• 73149-85-6 2-(3-Phenylsulfanyl-benzyl)-malonic acid diethyl ester 
• 73149-88-9 3-(3-Phenylsulfanyl-phenyl)-propionic acid 
• 73149-92-5 5-phenylsulfanyl-indan-1-one 
• 130920-14-8 (3-benzenesulfonyl-phenyl)-acetonitrile 
• 130920-13-7 (3-phenylsulfanyl-phenyl)-acetonitrile 
• 898535-17-6 methanesulfonic acid 3-phenylsulfanyl-benzyl ester 
• 73149-82-3 Sulfurous acid bis-(3-phenylsulfanyl-benzyl) ester 
• 73149-81-2 1-Chloromethyl-3-phenylsulfanyl-benzene 

Relevant academic research and scientific papers

NOVEL ANTIMALARIA AGENT CONTAINING HETEROCYCLIC COMPOUND

Disclosed is an antimalarial agent containing a compound represented by the formula: [wherein A1 represents a 3-pyridyl group that may have a substituent, a 6-quinolyl group that may have a substituent, or the like; X1 represents a group represented by the formula -C(=O)-NH- or the like; E represents a furyl group, a thienyl group or a phenyl group; with the proviso that A1 may have one to three substituents, and E has one of two substituents] or a salt thereof or hydrates thereof.

Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors

Various sulfonyl-containing compounds (e.g. sulfonamides, sulfones) bind at human 5-HT6 serotonin receptors, but it has been difficult relating the binding mode(s) of such agents to one another, even though many possess a common SO2 moiety, to identify a common pharmacophore model(s). On the basis of the hypothesis that an ergoline-type conformation might be important for the binding of some sulfonamide-containing arylalkylamines, we prepared for examination at h5-HT6 receptors a series of compounds, including phenylethylamines 6, pyrroloethylamine 7, and phenylpiperazines 9. The results (with Ki values ranging from about 1 nM to > 1000 nM) suggest that many of these agents likely bind in a related fashion, and structure-affinity studies indicate that the benzenesulfonamide portion of the phenylethylamine and phenylpiperazine analogues can be "reversed", abbreviated to a sulfone, and moved to an adjacent position with relatively little impact on affinity. Although a benzenesulfonamide (or related arylsulfonamide) group might be common to various 5-HT6 ligands, there appears to be some latitude with regard to the specific constitution and location of the sulfonamide moiety even within the same arylalkylamine structural framework. A pharmacophore model is presented to account for some of the current findings.