73149-92-5

Upstream product

• 73149-85-6 2-(3-Phenylsulfanyl-benzyl)-malonic acid diethyl ester 
• 5537-72-4 3-(phenylthio)benzoic acid 
• 73149-81-2 1-Chloromethyl-3-phenylsulfanyl-benzene 
• 55667-42-0 3-(phenylthio)benzenemethanol 
• 73149-88-9 3-(3-Phenylsulfanyl-phenyl)-propionic acid 

Relevant academic research and scientific papers

TETRALIN AND INDANE DERIVATIVES AND USES THEREOF AS 5-HT ANTAGONISTS

Compounds of the formula (I) or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R 2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula (I).

TETRALIN AND INDANE DERIVATIVES AND USES THEREOF

Compounds of the formula (I), or pharmaceutically acceptable salts thereof, wherein R2 is (CR3R4)n-NR5R6 and m, p, q, Ar, R1, R3, R4, R5 and R6 are as defined in the claims, which are selective antagonists of 5-HT6 and/or 5-HT2A. Also provided are compositions comprising these compounds and their use in the preparation of medicaments for treating central nervous system disease states selected from psychoses, schizophrenia, manic depressions, neurological disorders, memory disorders, attention deficit disorder, Parkinson’s disease, amyotrophic lateral scierosis, Alzheimer’s disease, food uptake disorders and Huntington’s disease.

TETRALIN AND INDANE DERIVATIVES AND USES THEREOF

Compounds of the formula (I) or pharmaceutically acceptable salts thereof, wherein R2 is a group of formula (II) and m, n, p, q, r, Rl and X are as defined in the claims, which are selective agonists of 5-HT6 and 5-HT2A. Also provided are compositions comprising these compounds and methods for their use in the preparation of medicaments for treating central nervous system disease states and disorders of the gastrointestinal tract.