556801-12-8

Basic information

• Product Name: C₂₂H₂₁N₃O₅
• CAS NO: 556801-12-8
• Molecular Weight: 407.426
• Mol File: 556801-12-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₁N₃O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₁N₃O₅(556801-12-8)
• EPA Substance Registry System: C₂₂H₂₁N₃O₅(556801-12-8)

Safety Data

• Hazardous Substances Data: 556801-12-8(Hazardous Substances Data)

Upstream product

• 2524-67-6 4-morpholino-4-yl-phenylamine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 161596-47-0 (S)-N-glycidylphthalimide 

Relevant articles and documents

Intermediate for synthesizing rivaroxaban, synthesizing method and application

The invention discloses an intermediate for synthesizing rivaroxaban, a synthesizing method and application. The synthesizing method comprises the following steps: firstly, carrying out addition reaction on a structure of formula II and a structure of formula III to obtain a corresponding amino alcohol compound, and then carrying out cyclization reaction on the amino alcohol compound and a carbonylation reagent to obtain a compound of the structure of formula I; carrying out oxidation reaction on the compound of the structure of formula I and an oxidizing agent to obtain a compound of a structure of known formula IV; secondly, desorbing phthaloyl from the compound of the structure of formula IV according to a known method to obtain a compound of a structure of known formula V; and finally,carrying out acylation reaction on the compound of the structure of formula V to obtain the rivaroxaban (a structure of formula VI). The solvent used in the addition reaction is isopropanol or ethanol, and the addition reaction is carried out at a room temperature or under a heating condition. The intermediate for synthesizing the rivaroxaban, the synthesizing method and the application are designed. The intermediate for synthesizing the rivaroxaban has the advantages of cheap and easily obtained raw materials, gentle and easily operated reaction conditions, environmental protection and lesspollution, high yield and purity, easiness in industrialization and the like.