55682-35-4Relevant academic research and scientific papers
Diversity-Oriented Synthesis of a Library of Star-Shaped 2H-Imidazolines
Yu, Xuepu,Guttenberger, Nikolaus,Fuchs, Elisabeth,Peters, Martin,Weber, Hansj?rg,Breinbauer, Rolf
, p. 682 - 690 (2015)
A library of star-shaped 2H-imidazolines has been synthesized via Debus-Radziszewski condensation from 1,2-diketones and ketone starting materials. Selective reduction of one imine group of the 2H-imidazole intermediate with LiAlH4 or catalytic flow hydrogenation furnished 2H-imidazolines, which could be conveniently diversified by reacting the amine N with electrophiles, resulting in a set of 21 amide-, carbamate-, urea-, and allylamine-containing products. In total, five points of diversification could be used, which allow the production of a set of functionally diverse compounds. The synthesis of acylated 2H-imidazolidines resulted in intrinsically labile compounds, which spontaneously degraded to acyclic derivatives, as shown for the reaction of 2H-imidazolidine with hexylisocyanate.
Quaternary Salts of 2H-Imidazoles
Katritzky, Alan R.,Borja, Susana Bravo,Marquet, Jorge,Sammes, Michael P.
, p. 2065 - 2069 (2007/10/02)
Treatment of the 4,5-diphenyl-2H-imidazoles (1a-e) with alkyl iodides gives novel 1H+,2H-imidazolium salts (2) and (3).The metho-salt (2) N-methyl protons are readily exchanged for deuterium, and anions formed by the action of base give, with m
