55686-94-7

Basic information

• Product Name: 2-CHLORO-7-NITROQUINOXALINE
• Synonyms: 2-CHLORO-7-NITROQUINOXALINE;TIMTEC-BB SBB014258
• CAS NO: 55686-94-7
• Molecular Formula: C₈H₄ClN₃O₂
• Molecular Weight: 209.59
• Mol File: 55686-94-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 188 °C
• Boiling Point: 350.5±37.0 °C(Predicted)
• Appearance: /
• Density: 1.566±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.57±0.30(Predicted)
• CAS DataBase Reference: 2-CHLORO-7-NITROQUINOXALINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-7-NITROQUINOXALINE(55686-94-7)
• EPA Substance Registry System: 2-CHLORO-7-NITROQUINOXALINE(55686-94-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 55686-94-7(Hazardous Substances Data)

Usage

General Description

2-Chloro-7-nitroquinoxaline is a chemical compound with the molecular formula C8H4ClN3O2. It is a yellow crystalline powder that is primarily used as a reagent in organic synthesis and pharmaceutical research. 2-CHLORO-7-NITROQUINOXALINE is known for its potential as an antiviral agent and has been studied for its activity against human immunodeficiency virus (HIV). It is also used as a fluorescent probe in neuroscience research, particularly in studies concerning ion channels and synaptic transmission. Additionally, 2-chloro-7-nitroquinoxaline has been investigated for its potential neuroprotective effects and its ability to modulate glutamate receptors. Overall, this chemical compound has demonstrated a range of useful applications in scientific research and drug development.

Upstream product

• 89898-96-4 2-Hydroxy-7-nitroquinoxaline 
• 95-54-5 1,2-diamino-benzene 
• 1196-57-2 2-hydroxyquinoxaline 
• 89898-96-4 7-nitroquinoxaline-2(1H)-one 
• 6639-87-8 6-nitroquinoxaline 
• 109541-16-4 7-nitroquinoxaline-N₁-oxide 

Downstream Products

• 1346245-18-8 C₃₀H₃₅F₃N₆O₄ 
• 1346245-19-9 C₂₈H₃₃N₅O₄ 
• 1346248-55-2 C₂₅H₂₉N₅O₃ 
• 1346245-17-7 C₂₆H₃₁N₅O₅S 
• 1346242-80-5 C₂₃H₂₅N₅O₃ 
• 1346245-15-5 C₂₄H₂₇N₅O₅S 

Relevant articles and documents

6-NITRO-2,3-DIPIPERIDINOQUINOXALINE: ITS UNEXPECTED FORMATION FROM 2-CHLORO-7-NITROQUINOXALINE

Excess piperidine and 2-chloro-7-nitroquinoxaline 1 in diethyl ether give large amounts of the unexpected disubstitution product 6-nitro-2,3-di-piperidinoquinoxaline 3.The mechanism of this very unusual nucleophilic substitution of hydrogen is suggested to involve the oxidation of the dipiperidino-dihydroquinoxaline 10 by dissolved oxygen.

QUINOXALINE COMPOUNDS AND USES THEREOF

Provided herein are compounds having a structure of formula (I) and methods of using the disclosed compounds to inhibit ΙΚΚβ activity.

Multi-gram preparation of 7-nitroquinoxalin-2-amine

Methodologies to obtain quinoxaline compounds regioselectively are rarely reported in literature, thus regioselective and multi-gram methodologies to obtain these derivatives are desirable to explore the entire potential of these scaffolds for academic and/or commercial application. A facile and multi-gram methodology is described to obtain compound 7-nitroquinoxalin-2-amine using o-phenylenediamine, a cheap and readily available reactant, as starting material in a five-step procedure in good yields and high purity without further purification such as crystallization or column chromatography.