6639-87-8

Basic information

• Product Name: 6-NITROQUINOXALINE
• Synonyms: TIMTEC-BB SBB009870;6-NITROQUINOXALINE;quinoxaline, 6-nitro-
• CAS NO: 6639-87-8
• Molecular Formula: C₈H₅N₃O₂
• Molecular Weight: 175.14
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Quinoxalines
• Mol File: 6639-87-8.mol
• Article Data: 29

Chemical Properties

• Melting Point: 169-171°C
• Boiling Point: 341.7 °C at 760 mmHg
• Flash Point: 160.5 °C
• Appearance: /
• Density: 1.437 g/cm³
• Vapor Pressure: 1.97E-07mmHg at 25°C
• Refractive Index: 1.694
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -2.07±0.30(Predicted)
• CAS DataBase Reference: 6-NITROQUINOXALINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-NITROQUINOXALINE(6639-87-8)
• EPA Substance Registry System: 6-NITROQUINOXALINE(6639-87-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 6639-87-8(Hazardous Substances Data)

Usage

General Description

6-NITROQUINOXALINE is a chemical compound with the molecular formula C8H5N3O4. It is a yellow crystalline solid that is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 6-NITROQUINOXALINE is also used in the production of dyes, pigments, and other organic compounds. It is known to be potentially hazardous if ingested, inhaled, or absorbed through the skin, and may cause irritation to the eyes, skin, and respiratory tract. Additionally, it is considered to be an environmental hazard and should be handled and disposed of with caution.

InChI:InChI=1/C8H5N3O2/c12-11(13)8-2-1-6-4-9-10-5-7(6)3-8/h1-5H

Upstream product

• 517-21-5 glyoxal sodium bisulfite 
• 99-56-9 4-Nitrophenylene-1,2-diamine 
• 91-19-0 2,3-diethynylquinoxaline 
• 3476-89-9 1,2,3,4-tetrahydroquinoxaline 
• 75-07-0 acetaldehyde 
• 107-21-1 ethylene glycol 
• 131543-46-9 Glyoxal 
• 141090-51-9 6-nitro-1,4-dinitroso-1,2,3,4-tetrahydroquinoxaline 

Downstream Products

• 2379-56-8 6-nitro-1,2,3,4-tetrahydroquinoxaline-2,3-dione 
• 6298-37-9 6-aminoquinoxaline 
• 109297-27-0 6-nitro-2-<(p-tolylsulfonyl)methyl>quinoxaline 
• 129919-32-0 6-nitro-2-<1-(phenylsulfonyl)ethyl>quinoxaline 
• 115726-26-6 2-amino-6-nitroquinoxaline 
• 57436-91-6 5-amino-6-nitroquinoxaline 
• 50358-63-9 5-bromo-6-amino-quinoxaline 
• 6272-25-9 2-Chloro-6-nitroquinoxaline 
• 55686-94-7 2-Chloro-7-nitroquinoxaline 
• 109541-21-1 6-chloro-7-nitroquinoxaline 
• 109504-68-9 N-quinoxalin-6-yl-toluene-4-sulfonamide 
• 100881-61-6 N-(5-nitro-quinoxalin-6-yl)-toluene-4-sulfonamide 
• 57436-95-0 quinoxaline-5,6-diamine 
• 888037-23-8 N6-methylquinoxaline-5,6-diamine 

Relevant articles and documents

Pressure Effects on the Thermal Decomposition of Nitramines, Nitrosamines, and Nitrate Esters

Solutions of nitramine and nitrate ester explosives and model compounds were thermolyzed at various hydrostatic pressures and their rates of decomposition were measured.The effects of pressure on their rates were used to infer the mechanism of their initi

Metal-free regioselective nitration of quinoxalin-2(1H)-ones withtert-butyl nitrite

A metal-free coupling of quinoxalin-2(1H)-ones withtert-butyl nitrite has been developed. Distinctly from the previous functionalization of quinoxalin-2(1H)-ones, this nitration reaction took place selectively at the C7 or C5 position of the phenyl ring, affording a series of 7-nitro and 5-nitro quinoxalin-2(1H)-ones in moderate to good yields. Preliminary mechanistic studies revealed that the reaction may involve a radical process.

Thiazolo[5,4-f]quinoxalines, Oxazolo[5,4-f]quinoxalines and Pyrazino[b,e]isatins: Synthesis from 6-Aminoquinoxalines and Properties

The regioselective iodination of different 2-mono-, 3-mono- and 2,3-disubstituted 6-aminoquinoxalines, which takes place at their 5-position, was rationalized on the basis of Hückel theory calculations. Oxazolo- and thiazolo[5,4-f]quinoxaline analogues of

Compound used as EGFR kinase inhibitor and application thereof

The invention relates to a compound used as an EGFR kinase inhibitor and application thereof, the compound has a structure as shown in a formula I, and the compound can be used for adjusting EGFR kinase activity or treating related diseases, especially non-small cell lung cancer.