55687-20-2Relevant academic research and scientific papers
Synthesis and SAR of novel imidazoquinoxaline-based Lck inhibitors: Improvement of cell potency
Chen, Ping,Iwanowicz, Edwin J.,Norris, Derek,Gu, Henry H.,Lin, James,Moquin, Robert V.,Das, Jagabandhu,Wityak, John,Spergel, Steven H.,De Fex, Henry,Pang, Suhong,Pitt, Sydney,Shen, Ding Ren,Schieven, Gary L.,Barrish, Joel C.
, p. 3153 - 3156 (2007/10/03)
A series of anilino(imidazoquinoxaline) analogues bearing solubilizing side chains at the 6- and 7-positions of the fused phenyl ring has been prepared and evaluated for inhibition against Lck enzyme and of T-cell proliferation. Significant improvement of the cellular activity was achieved over the initial lead, compound 2.
Reaction of quinoxalin-2-ones with TosMIC reagent: Synthesis of imidazo[1,5-a]quinoxalin-4-ones
Chen, Ping,Barrish, Joel C.,Iwanowicz, Edwin,Lin, James,Bednarz, Mark S.,Chen, Bang-Chi
, p. 4293 - 4295 (2007/10/03)
Imidazo[1,5-a]quinoxalin-4-ones were prepared in four steps starting from 1,2-phenylenediamines using a new strategy for the construction of the ring system. A key step in this new method involves the reaction of quinoxalin-2-ones with TosMIC (tosylmethyl isocyanide).
