55690-60-3

Basic information

• Product Name: 2-MERCAPTO-5-METHOXYBENZOTHIAZOLE
• Synonyms: 2-MERCAPTO-5-METHOXYBENZOTHIAZOLE;5-METHOXYBENZOTHIAZOLE-2-THIOL;5-methoxybenzothiazole-2(3H)-thione;2-MERCAPTO-5-METHOXYBENZOTHIAZOLE 98+%;2(3H)-Benzothiazolethione,5-methoxy-(9CI);5-Methoxy-2(3H)-benzothiazolethione;5-Methoxy-2-benzothiazolethiol;5-Methoxy-2-mercaptobenzothiazole
• CAS NO: 55690-60-3
• Molecular Formula: C₈H₇NOS₂
• Molecular Weight: 197.28
• EINECS: 259-755-1
• Product Categories: BENZOTHIAZOLE
• Mol File: 55690-60-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 190-193°C
• Boiling Point: 340.8°C at 760 mmHg
• Flash Point: 159.9°C
• Appearance: /
• Density: 1.44g/cm³
• Vapor Pressure: 8.38E-05mmHg at 25°C
• Refractive Index: 1.728
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.27±0.20(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 142225
• CAS DataBase Reference: 2-MERCAPTO-5-METHOXYBENZOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-MERCAPTO-5-METHOXYBENZOTHIAZOLE(55690-60-3)
• EPA Substance Registry System: 2-MERCAPTO-5-METHOXYBENZOTHIAZOLE(55690-60-3)

Safety Data

• Safety Statements: 22-24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 55690-60-3(Hazardous Substances Data)

Usage

Uses

2-Mercapto-5-methoxybenzothiazole is used as an intermediate in organic synthesis.

InChI:InChI=1/C8H7NOS2/c1-10-5-2-3-7-6(4-5)9-8(11)12-7/h2-4H,1H3,(H,9,11)

Upstream product

• 27191-09-9 m-anisidine hydrochloride 
• 10298-80-3 2-chloro-5-methoxynitrobenzene 
• 75-15-0 carbon disulfide 
• 14482-32-7 2-amino-4-methoxybenzenethiol 
• 2401-24-3 2-chloro-5-methoxyaniline 
• 140-89-6 potassium ethyl xanthogenate 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 153898-63-6 2-iodo-5-methoxyaniline 

Downstream Products

• 38519-79-8 [4-(2-diethylamino-ethoxy)-phenyl]-(5-methoxy-benzothiazol-2-yl)-amine 
• 3507-37-7 5-methoxy-2-methylsulfanyl-1,3-benzothiazole 
• 562826-61-3 2-(methylthio)benzo[d]thiazol-5-ol 
• 1207869-03-1 (4-bromo-5-hydroxybenzo[d]thiazol-2-yl)(4-phenoxyphenyl)methanone 
• 1207869-49-5 (4,6-dibromo-5-hydroxybenzo[d]thiazol-2-yl)(4-phenoxyphenyl)methanone 
• 1207869-02-0 (5-hydroxybenzo[d]thiazol-2-yl)(4-phenoxyphenyl)methanone 
• 1207869-71-3 (5-mehoxybenzo[d]thiazol-2-yl)(4-phenoxyphenyl)methanone 
• 3507-28-6 (4,6-dibromo-5-hydroxybenzofuran-2-yl)(4-phenoxyphenyl)methanone 

Relevant articles and documents

A 5-methoxy-2-mercaptobenzothiazole method for the preparation of (by machine translation)

The invention relates to a 5-methoxy-2-mercaptobenzothiazole preparation method, comprising the following steps: adding sodium sulfide aqueous solution in the reactor, 4-chloro-3-nitroanisole, carbon disulfide is added under stirring, microwave heating to 50-95°C, the reaction to the raw dematerialised, stop the reaction, cooling to room temperature, the pH of the reaction to in the fluid adds the acid 3-5, filtering, drying to obtain 5-methoxy-2-mercaptobenzothiazole. The preparation method of this invention is the synthesis of 5-methoxy-2-mercaptobenzothiazole the new route, the process is relatively simple, easy availability of raw materials, reagents for the process of operation and relatively low toxicity, and mild reaction conditions, time is short, high yield, low cost at the same time, less wastes, high content of target products, is particularly suitable for industrial production. (by machine translation)

Analogues of the allosteric heat shock protein 70 (Hsp70) inhibitor, MKT-077, as anti-cancer agents

The rhodacyanine, MKT-077, has antiproliferative activity against cancer cell lines through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. However, MKT-077 is rapidly metabolized, which limits its use as either a chemical probe or potential therapeutic. We report the synthesis and characterization of MKT-077 analogues designed for greater stability. The most potent molecules, such as 30 (JG-98), were at least 3-fold more active than MKT-077 against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50 values of 0.4 ± 0.03 and 0.7 ± 0.2 μM, respectively). The analogues modestly destabilized the chaperone clients, Akt1 and Raf1, and induced apoptosis in these cells. Further, the microsomal half-life of JG-98 was improved at least 7-fold (t1/2 = 37 min) compared to MKT-077 (t1/2 5 min). Finally, NMR titration experiments suggested that these analogues bind an allosteric site that is known to accommodate MKT-077. These studies advance MKT-077 analogues as chemical probes for studying Hsp70s roles in cancer.

METHOXYACRYLATE-BASED FUNGICIDE AND METHODS FOR PREPARING AND USING THE SAME

A pharmaceutical composition of fungicide including at least a compound represented by Formula (I). The pharmaceutical composition of fungicide can further include an emulsifier, a cosolvent, a stabilizer, and a solvent. The fungicide can prevent and treat powdery mildew, downy mildew, gray mold, brown spot, scab of vegetables and fruits, southern leaf blight of corn, rice false smut, citrus stem-end rot, and rape sclerotinia rot, with high efficiency, low toxicity, and relative environmental friendliness. A method of preparing the fungicide and a method of using thereof are also provided.