55739-98-5Relevant academic research and scientific papers
Distinct chemoselectivity in the reaction of N-(thio)phosphoryl imines with diethylzinc
Ma, Xinpeng,Xu, Xinyuan,Wang, Chungui,Zhao, Guofeng,Zhou, Zhenghong,Tang, Chuchi
, p. 3685 - 3690 (2007)
This report describes the reaction of N-(thio)phosphoryl imines with diethylzinc under different conditions. An interesting and distinct chemoselectivity between hydrogen-addition and ethyl-addition to imine double bond is disclosed: in weakly polar solve
Catalytic enantioselective alkylation of aldehydes using chiral hydrogen phosphoramidates and hydrogen phosphinamides and their thio analogs
Soai, Kenso,Ohno, Yoshiaki,Inoue, Yukikazu,Tsuruoka, Toshihiro,Hirose, Yuji
, p. 145 - 152 (2007/10/02)
Chiral (enantiomerically pure) hydrogen thiophosphoramidates and hydrogen phosphoramidates and their phosphinamide analogs derived from norephedrine and other chiral (enantiomerically pure) amino alcohols catalyze the enantioselective addition of dialkylzincs to aldehydes.The presence of titanium tetraisopropoxide increases the enantioselectivity, providing enantiomerically enriched secondary alcohols with up to 98percent ee.The enantioselectivities of thiophosphoramidates and thiophosphinamides are higher than those of the oxygen analogs.The phosphoramidates and thiophosphoramidates, without the hydroxyl group, also catalyze the addition of dialkylzinc to aldehydes in the absence of Ti(O-i-Pr)4.
HYDROBORATION OF UNSATURATED AMINES VIII A CONVENIENT SYNTHESIS OF AMINO-3 PROPANOL-1
Benmaarouf-Khallaayoun, Z.,Baboulene, M.,Speziale, V.,Lattes, A.
, p. 233 - 242 (2007/10/02)
A new route with increased yield and stereoselectivity is reported for the synthesis of amino-3 propanols-1.It involved a hydroboration-oxidation reaction using bora- 9 bicyclo nonane.The amino group was protected by a phosphorylated grouping giving rise to novel and potentially useful phosphorylated reagents.
