55760-09-3Relevant academic research and scientific papers
Asymmetric Hydrogenation of Racemic Allylic Alcohols via an Isomerization-Dynamic Kinetic Resolution Cascade
Wang, Kun,Niu, Saisai,Guo, Xin,Tang, Weijun,Xue, Dong,Xiao, Jianliang,Sun, Huaming,Wang, Chao
supporting information, p. 3804 - 3809 (2022/02/05)
Prochiral racemic allylic alcohols are converted to enantioenriched chiral alcohols bearing adjacent stereocenters catalyzed by a diamine diphosphine Ru complex in the presence of tBuOK. The protocol features a broad substrate scope (56 examples) and high
Synthesis of Some Multi-cyclic Sulfhydryl Donor Compounds Containing 1,2-dithiol-3-thione moiety
Al-Iraqi, Mohammed Ahmed,Hamdoon, Ahmed M.,Saleh, Mohanad Yakdan
, p. 419 - 426 (2022/02/21)
1,2-Dithiol-3-thiones are a sulfur containing five membered heterocyclic compounds, which constitute an important class of biologically active compounds owing to their ability to release sulfhydryl (SH) group. In this research a new series of multi-cyclic
Copper/GanPhos-Catalyzed 1,3-Dipolar Cycloaddition of Azo?-methine Ylides: An Efficient Access to Chiral Pyrrolidine Spirocycles
Gan, Zhenjie,Li, Ke,Zhang, Hui,Li, Er-Qing
supporting information, p. 1331 - 1340 (2020/11/30)
A highly efficient copper/GanPhos-catalyzed 1,3-dipolar cyclo?-addition?-of azomethine ylides is reported. This viable transformation provides a series of optically active spiro[dihydronaphthalene-2,3′-pyrrolidine]s, bearing one spiro quaternary and three tertiary stereogenic centers, in good yields and with high ee values. This protocol features high diastereo- A nd enantioselectivity, broad substrate scope and mild reaction conditions.
Claisen-Schmidt, aza-Michael, cyclization via cascade strategy toward microwave promoted synthesis of imidazo[2,1-b]quinazolines
Devi Priya, Duraipandi,Mohana Roopan, Selvaraj
, p. 1813 - 1834 (2020/05/25)
Imidazole blended quinazolines are having a wide run of potential applications in synthetic field. In this current investigation, we reported a modern synthesis with the help of non-conventional energy. Optimization parameters have been stabilized utilizi
A simple iron-catalyst for alkenylation of ketones using primary alcohols
Sk, Motahar,Kumar, Ashish,Das, Jagadish,Banerjee, Debasis
, (2020/04/10)
Herein, we developed a simple iron-catalyzed system for the α-alkenylation of ketones using primary alcohols. Such acceptor-less dehydrogenative coupling (ADC) of alcohols resulted in the synthesis of a series of important α,β-unsaturated functionalized ketones, having aryl, heteroaryl, alkyl, nitro, nitrile and trifluoro-methyl, as well as halogen moieties, with excellent yields and selectivity. Initial mechanistic studies, including deuterium labeling experiments, determination of rate and order of the reaction, and quantitative determination of H2 gas, were performed. The overall transformations produce water and dihydrogen as byproducts.
Manganese(I)-Catalyzed α-Alkenylation of Ketones Using Primary Alcohols
Gawali, Suhas Shahaji,Pandia, Biplab Keshari,Gunanathan, Chidambaram
supporting information, p. 3842 - 3847 (2019/05/24)
A simple protocol of manganese catalyzed selective α-alkenylation of ketones using primary alcohols is reported. The reactions proceeded well with a low loading of catalyst (0.3 mol %). The overall transformation operates through O-H bond activation of pr
Selectivity in the Aerobic Dearomatization of Phenols: Total Synthesis of Dehydronornuciferine by Chemo- and Regioselective Oxidation
Esguerra, Kenneth Virgel N.,Lumb, Jean-Philip
supporting information, p. 1514 - 1518 (2018/01/27)
We describe a selective aerobic oxidation of meta-biaryl phenols that enables rapid access to functionalized phenanthrenes. Aerobic oxidations attract interest due to their efficiency, but remain underutilized in complex molecule settings due to challenge
Organic compound and composition and organic optoelectric device and display device
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Paragraph 0156-0159, (2015/12/08)
Disclosed are an organic compound represented by the following Chemical Formula 1, a composition for an organic optoelectric device including the organic compound, an organic optoelectric device including the organic compound or the composition, and a display device including the organic optoelectric device. In the Chemical Formula 1, X, L1 to L6, R1 to R22, and n1 to n4 are the same as described in the detailed description.
UV-light induced domino type reactions: Synthesis and photophysical properties of unreported nitrogen ring junction quinazolines
Palaniraja, Jeyakannu,Roopan, Selvaraj Mohana
, p. 37415 - 37423 (2015/05/20)
An expedient method for the synthesis of 5,6-dihydrobenzo[h][1,2,4]triazolo[5,1-b]quinazolines by UV light has been developed. Our aim was to synthesize various α, β-unsaturated carbonyl compounds and to further react them with different amines in DMF, in
Design, synthesis, and interaction study of quinazoline-2(1 H)-thione derivatives as novel potential Bcl-xL inhibitors
Feng, Yu,Ding, Xiao,Chen, Tao,Chen, Lili,Liu, Fang,Jia, Xu,Luo, Xiaomin,Shen, Xu,Chen, Kaixian,Jiang, Hualiang,Wang, Hui,Liu, Hong,Liu, Dongxiang
experimental part, p. 3465 - 3479 (2010/09/05)
Development of inhibitors to antagonize the activities of antiapoptotic Bcl-2 family proteins is of particular interest in cancer chemotherapy. We discovered a quinazoline-2(1H)-thione derivative (DCBL55) as a new Bcl-x L, Bcl-2, and Mcl-1 inhi
