55760-26-4

Basic information

• Product Name: 1-(Trimethylsilyl)-9,10-didehydro-N,N-diethyl-6-methylergoline-8β-carboxamide
• Synonyms: 1-(Trimethylsilyl)-9,10-didehydro-N,N-diethyl-6-methylergoline-8β-carboxamide;1-(Trimethylsilyl)LSD;N,N-Diethyl-9,10-didehydro-6-methyl-1-(trimethylsilyl)ergoline-8β-carboxamide
• CAS NO: 55760-26-4
• Molecular Formula: C23H33N3OSi
• Molecular Weight: 395.61312
• Mol File: 55760-26-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(Trimethylsilyl)-9,10-didehydro-N,N-diethyl-6-methylergoline-8β-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Trimethylsilyl)-9,10-didehydro-N,N-diethyl-6-methylergoline-8β-carboxamide(55760-26-4)
• EPA Substance Registry System: 1-(Trimethylsilyl)-9,10-didehydro-N,N-diethyl-6-methylergoline-8β-carboxamide(55760-26-4)

Safety Data

• Hazardous Substances Data: 55760-26-4(Hazardous Substances Data)

Upstream product

• 25561-30-2 N,O-Bis(trimethylsilyl)trifluoroacetamide 
• 2126-78-5 lysergic acid diethylamide 
• 50-37-3 lysergide 

Relevant articles and documents

Determination of lysergic acid diethylamide (LSD), iso-LSD, and N-demethyl-LSD in body fluids by gas chromatography/ tandem mass spectrometry

Procedures for detection and quantitation of lysergic acid diethylamide (LSD), iso-LSD, and N-demethyl-LSD by capillary chromatography/tandem mass spectrometry (GC/MS/MS) are presented. Several methods for derivatization, sample introduction, and ionization, in combination with mass spectrometry/mass spectrometry (MS/MS), have been evaluated for overall ionization efficiency and product-ion sensitivity and specificity. Fragmentation pathways derived from low-energy collision-induced dissociation (CID) spectra of protonated LSD, and the protonated trimethylsilyl derivatives of LSD (LSD-TMS) and deuterium-labeled analogs of LSD, have been proposed. Principal dissociations primarily involve the amide and piperidine-ring moieties in which losses of CH3 radical, CH3NH2, CH3NCH2, diethylamine, diethylformamide, and N,N-diethylpropenamide from MH+ are observed. Positive-ion ammonia chemical ionization and subsequent MS/MS analysis of the protonated molecules (MH+) of the trimethylsilyl (TMS) derivatives of LSD, iso-LSD, and N-demethyl-LSD provide a high degree of specificity for identification of these compounds in urine or blood at low-pg/mL concentrations. Negative-ion chemical ionization and GC/MS/MS analysis of the molecular anion (M-) of the trifluoroacetyl (TFA) derivative is well suited for trace-level identification of N-demethyl-LSD, a metabolite of LSD.