55776-07-3Relevant academic research and scientific papers
Novel inhibitors of NRH:Quinone oxidoreductase 2 (NQO2): Crystal structures, biochemical activity, and intracellular effects of imidazoacridin-6-ones
Dunstan, Mark S.,Barnes, John,Humphries, Matthew,Whitehead, Roger C.,Bryce, Richard A.,Leys, David,Stratford, Ian J.,Nolan, Karen A.
experimental part, p. 6597 - 6611 (2011/12/01)
Imidazoacridin-6-ones are shown to be potent nanomolar inhibitors of the enzyme NQO2. By use of computational molecular modeling, a reliable QSAR was established, relating inhibitory potency with calculated binding affinity. Further, crystal structures of
Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2
Nolan, Karen A.,Humphries, Matthew P.,Barnes, John,Doncaster, Jeremy R.,Caraher, Mary C.,Tirelli, Nicola,Bryce, Richard A.,Whitehead, Roger C.,Stratford, Ian J.
experimental part, p. 696 - 706 (2010/07/04)
A range of triazoloacridin-6-ones functionalized at C5 and C8 have been synthesized and evaluated for ability to inhibit NQO1 and NQO2. The compounds were computationally docked into the active site of NQO1 and NQO2, and calculated binding affinities were
Use of 2,6-Dichlorobenzonitrile (Dichlobenil) as Starting Material for Synthesis of Herbicides, Derivatives of Benzoic Acid.
Romanowski,Wituch-Zapalowska,Eckstein
, p. 26 - 31,27, 28, 30 (2007/10/06)
Results of an investigation are presented in which S//N reactions of dichlobenil and its transformation products were investigated using as nucleophilic agents for chlorine exchange: sodium methanolate and ethanolate, as well as aniline and its derivatives. It has been shown that the ability to enter the reaction of mono- or disubstitution is dependent on the kind of derivative of 2,6-dichloro-3-nitrobenzoic acid, as well as on conditions of reactions. In the manner described above, dichlobenil has been transformed into valuable herbicide, dicamba, i. e. 3,6-dichloro-2-methoxybenzoic acid. A mixture of isomeric acids has been obtained, their herbicide activity having the same range.
