557798-60-4

Upstream product

• 105184-38-1 3,5-difluorophenyl acetic acid 
• 210530-70-4 methyl 2-(3,5-difluorophenyl)acetate 
• 132741-31-2 S-(+)-3.5-Difluoromandelic Acid 
• 208259-37-4 methyl 2-(3,5-difluorophenyl)-2-hydroxyacetate 

Downstream Products

• 253324-75-3 α-(((1,1,-dimethylethoxy)carbonyl)amino)-3,5-difluorobenzeneacetic acid 
• 1194752-26-5 α-amino-3,5-difluorobenzeneacetamide 
• 1194752-16-3 α-(((1,1,-dimethylethoxy)carbonyl)amino)-3,5-difluorobenzeneacetic acid methyl ester 
• 1194752-23-2 α-(((1,1,-dimethylethoxy)carbonyl)amino)-3,5-difluorobenzeneacetamide 
• 1194752-29-8 α-(4-chlorobenzenesulfonylamino)-3,5-difluorobenzeneacetamide 
• 1310689-77-0 (S)-α-(4-chlorobenzenesulfonylamino)-3,5-difluorobenzeneacetamide 
• 1310689-74-7 (R)-α-(4-chlorobenzenesulfonylamino)-3,5-difluorobenzeneacetamide 
• 1194751-22-8 α-((4-chlorobenzenesulfonyl)((4-carboxyphenyl)methyl)amino)-3,5-difluorobenzeneacetamide 
• 1194751-70-6 α-((4-chlorobenzenesulfonyl)(4-(4-(1,2,4-oxadiazol-3-yl)phenyl)methyl)amino)-3,5-difluorobenzeneacetamide 
• 1194751-18-2 α-((4-chlorobenzenesulfonyl)((4-t-butyloxycarbonylphenyl)methyl)amino)-3,5-difluorobenzeneacetamide 
• 1194753-64-4 (S)-α-((4-chlorobenzenesulfonyl)(4-(4-(1,2,4-oxadiazol-3-yl)phenyl)methyl)amino)-3,5-difluorobenzeneacetamide 
• 1194753-67-7 (R)-α-((4-chlorobenzenesulfonyl)(4-(4-(1,2,4-oxadiazol-3-yl)phenyl)methyl)amino)-3,5-difluorobenzeneacetamide 
• 1194751-25-1 α-((4-chlorobenzenesulfonyl)((4-ethylaminocarbonylphenyl)methyl)amino)-3,5-difluorobenzeneacetamide 
• 1194751-67-1 α-((4-chlorobenzenesulfonyl)(4-(4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)methyl)amino)-3,5-difluorobenzeneacetamide 

Relevant academic research and scientific papers

New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols

S-nitrosothiols (RSNOs) remain one of the most popular classes of NO-donating compounds due to their ability to release nitric oxide (NO) under non-enzymatic means whilst producing an inert disulphide by-product. However, alligning these compounds to the different biological fields of NO research has proved to be problematic due to the inherent instability of such compounds under a variety of conditions including heat, light and the presence of copper ions. 1,3,2-Oxathiazolylium-5-olates (OZOs) represent an interesting subclass of S-nitrosothiols that lock the –SNO moiety into a five membered heterocyclic ring in an attempt to improve the compound's overall stability. The synthesis of a novel series of halogen-containing OZOs was comprehensively studied resulting in a seven-step route and overall yields ranging between 21 and 37%. The photochemical stability of these compounds was assessed to determine if S-nitrosothiols locked within these mesoionic ring systems can offer greater stability and thereby release NO in a more controllable fashion than their non-cyclic counterparts.

MINERALOCORTICOID RECEPTOR ANTAGONISTS

Disclosed are the compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, which are useful for treating aldosterone-mediated diseases. The processes for preparing compounds of the Formula (I), the use for the therapy and prophyl

2-ARYL GLYCINAMIDE DERIVATIVES

The disclosure provides compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their uses in inhibiting β-amyloid peptide ( β-AP) production.