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210530-70-4

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210530-70-4 Usage

Uses

(3,5-Difluoro-phenyl)acetic Acid Methyl Ester was studied for its usefulness as an antibiotic. It is also used as a reactant in the synthesis of diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus.

Check Digit Verification of cas no

The CAS Registry Mumber 210530-70-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,0,5,3 and 0 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 210530-70:
(8*2)+(7*1)+(6*0)+(5*5)+(4*3)+(3*0)+(2*7)+(1*0)=74
74 % 10 = 4
So 210530-70-4 is a valid CAS Registry Number.

210530-70-4Relevant articles and documents

Pyrrolidone derivative

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Paragraph 0146; 0150-0151, (2021/03/13)

The present invention relates to a pyrrolidone derivative and a pharmaceutically acceptable composition thereof, which are useful as inhibitors of methionine aminopeptidase.

SGC STIMULATORS

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Page/Page column 00262, (2018/05/27)

The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an inc

Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design

Hamada, Yoshio,Tagad, Harichandra D.,Nishimura, Yoshinori,Ishiura, Shoichi,Kiso, Yoshiaki

scheme or table, p. 1130 - 1135 (2012/03/26)

Previously reported pentapeptidic BACE1 inhibitors, designed using a substrate-based approach, were used as lead compounds for the further design of non-peptidic BACE1 inhibitors. Although these peptidic and non-peptidic inhibitors, with a hydroxymethylcarbonyl isostere as a substrate transition-state mimic, exhibited potent BACE1 inhibitory activities, their molecular-sizes appeared a little too big (molecular weight of >600 daltons) for developing practical anti-Alzheimer's disease drugs. To develop lower weight BACE1 inhibitors, a series of tripeptidic BACE1 inhibitors were devised using a design approach based on the conformation of a virtual inhibitor bound to the BACE1 active site, also called 'in-silico conformational structure-based design'. Although these tripeptidic BACE1 inhibitors contained some natural amino acid residues, they are expected to be useful as lead compounds for developing the next generation BACE1 inhibitors, due to their low molecular size and unique structural features compared with previously reported inhibitors.

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