55789-02-1

Basic information

• Product Name: Benzenemethanol, a-ethyl-3-hydroxy-
• CAS NO: 55789-02-1
• Molecular Formula: C9H12O2
• Molecular Weight: 152.193
• Mol File: 55789-02-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-ethyl-3-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-ethyl-3-hydroxy-(55789-02-1)
• EPA Substance Registry System: Benzenemethanol, a-ethyl-3-hydroxy-(55789-02-1)

Safety Data

• Hazardous Substances Data: 55789-02-1(Hazardous Substances Data)

Upstream product

• 13103-80-5 1-(3-hydroxyphenyl)propan-1-one 
• 74-96-4 ethyl bromide 
• 925-90-6 ethylmagnesium bromide 
• 100-83-4 meta-hydroxybenzaldehyde 
• 1700-37-4 3-Benzyloxybenzaldehyde 

Downstream Products

• 621-27-2 3-n-propylphenol 
• 13103-80-5 1-(3-hydroxyphenyl)propan-1-one 
• 166337-52-6 1-(3-allyloxyphenyl)propanol 
• 134154-10-2 2-{1-Methoxy-1-[3-(naphthalen-2-ylmethoxy)-phenyl]-propyl}-4-methyl-thiazole 
• 134154-32-8 1-(4-Methyl-thiazol-2-yl)-1-[3-(naphthalen-2-ylmethoxy)-phenyl]-propan-1-ol 
• 129446-99-7 1-[3-(Naphthalen-2-ylmethoxy)-phenyl]-1-thiazol-2-yl-propan-1-ol 
• 129425-69-0 1-<3-(naphth-2-ylmethoxy)phenyl>propan-1-one 
• 94103-10-3 methyl 5-iodo-4-(2-iodo-5-methoxy-4-nitro-3-propylphenoxy)-2-methoxy-6-pentylbenzoate 
• 94103-09-0 methyl 5-iodo-4-(5-methoxy-4-nitro-3-propylphenoxy)-2-methoxy-6-pentylbenzoate 
• 94103-05-6 methyl 5-bromo-4-(5-methoxy-4-nitro-3-propylphenoxy)-2-methoxy-6-pentylbenzoate 
• 94103-04-5 methyl 2-methoxy-4-(5-methoxy-4-nitro-3-propylphenoxy)-6-pentylbenzoate 
• 94102-96-2 5-Bromo-1-methoxy-2-nitro-3-propyl-benzene 
• 94102-94-0 1-Bromo-5-methoxy-2-nitro-3-propyl-benzene 
• 94102-98-4 1-Bromo-3-methoxy-2-nitro-5-propyl-benzene 

Relevant articles and documents

A practical synthesis of 3-n-propylphenol, a component of tsetse fly attractant blends

A practical synthesis of the tsetse fly attractant 3-n-propylphenol involves the Grignard reaction of 3-hydroxybenzaldehyde and ethylmagnesium bromide affording a benzylic alcohol-type phenol derivative that upon catalytic hydrogenation gives the title product in 75% overall yield. Selection of the right solvent mixture and temperature range for the Grignard reaction is crucial for the kilogram-scale preparation of the target compound.

5-LIPOXYGENASE INHIBITORY THIAZOLES

The invention concerns a thiazole of the formula I, wherein Ar1 is optionally substituted aryl of up to 10 carbon atoms; A is a direct link to X, or is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene; X is oxy, thio, sulphinyl, sulphonyl or imino; Ar2 is optionally substituted phenylene, or a 6-membered heterocyclene moiety containing up to three nitrogen atoms; R1 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl; R2 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, substituted (1-4C)alkyl or (2-6C)alkanoyl; Q is optionally substituted thiazolyl; or a pharmaceutically-acceptable salt thereof. The invention also concerns processes for the manufacture of a thiazole of the formula I, or a pharmaceutically-acceptable salt thereof, and pharmaceutical compositions containing said thiazole

Thiazole derivatives having a 5-lipoxygenase-inhibiting activity

The invention concerns a thiazole of the formula I, wherein Ar1 is optionally substituted aryl of up to 10 carbon atoms;, A is a direct link to X, or is (1-6C)alkylene, (3-6C)alkenylene, (3--6C)alkynylene or cyclo(3-6C)alkylene;, X is oxy, thio, sulphinyl, sulphonyl or imino;, Ar2 is optionally substituted phenylene,or a 6-membered heterocyclene moiety containing up to three nitrogen atoms;, R1 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl;, R2 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, substituted (1-4C)alkyl or (2-6C)alkanoyl;, Q is optionally substituted thiazolyl;, or a pharmaceutically-acceptable salt thereof. The invention also concerns processes for the manufacture of a thiazole of the formula I, or a pharmaceutically-acceptable salt thereof, and pharmaceutical compositions containing said thiazole.